ArticleBiomedical optics express2020
High-throughput 3D imaging of single cells with light-sheet fluorescence microscopy on chip.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Patch deconvolution for Fourier light-field microscopy.Biophysical journal · 2026Article
- Technological innovations and high-throughput applications of light-sheet microscopy.Biophysics reports · 2026Article
- Fast interrogation of intestinal organ-on-chip devices through inverted single-plane illumination microscopy (iSPIM) using an electro-tunable lens.Biomedical optics express · 2025Article
- Femtosecond laser microfabrication of a fully-integrated optofluidic device for 3D imaging flow cytometry.Scientific reports · 2025Article
- Novel application of metabolic imaging of early embryos using a light-sheet on-a-chip device: a proof-of-concept study.Human reproduction (Oxford, England) · 2025Article
- Review
- Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models.Journal of functional biomaterials · 2024Review
- Modelling and targeting mechanical forces in organ fibrosis.Nature reviews bioengineering · 2024Article
- Light-field flow cytometry for high-resolution, volumetric and multiparametric 3D single-cell analysis.Nature communications · 2024Article
- Portable light-sheet optofluidic microscopy for 3D fluorescence imaging flow cytometry.Lab on a chip · 2023Article
- SPIM-Flow: An Integrated Light Sheet and Microfluidics Platform for Hydrodynamic Studies ofBiology · 2023Article
- Artificial intelligence in imaging flow cytometry.Frontiers in bioinformatics · 2023Article
- High-Throughput Parallel Optofluidic 3D-Imaging Flow Cytometry.Small science · 2022Article
- High-speed 3D imaging flow cytometry with optofluidic spatial transformation.Biomedical optics express · 2022Article
- Blind deconvolution in autocorrelation inversion for multiview light-sheet microscopy.Microscopy research and technique · 2022Article
- Smart imaging to empower brain-wide neuroscience at single-cell levels.Brain informatics · 2022Review
- Microscopic Imaging Methods for Organ-on-a-Chip Platforms.Micromachines · 2022Review
- Modular multimodal platform for classical and high throughput light sheet microscopy.Scientific reports · 2022Article
- Improving axial resolution in Structured Illumination Microscopy using deep learning.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- GPU-accelerated real-time reconstruction in Python of three-dimensional datasets from structured illumination microscopy with hexagonal patterns.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-cell analysis techniques are fundamental to study the heterogeneity of cellular populations, which is the basis to understand several biomedical mechanisms. Light-sheet fluorescence microscopy is a powerful technique for obtaining high-resolution imaging of individual cells, but the complexity of the setup and the sample mounting procedures limit its overall throughput. In our work, we present an optofluidic microscope-on-chip with integrated microlenses for light-sheet shaping and with a fluidic microchannel that allows the automatic and continuous delivery of samples of a few tens of microns in size. The device is used to perform dual-color fluorescence analysis and 3D reconstruction of xenograft-derived mouse breast cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.