ArticleBiomedical optics express2020
Performance of measurands in time-domain optical brain imaging: depth selectivity versus contrast-to-noise ratio.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Sensitivity factors for diffuse optics - derivation of equations for finite changes.Biomedical optics express · 2026Article
- Phase-based structured interrogation frequency-domain near-infrared spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Time-domain diffuse correlation spectroscopy at large source detector separation for cerebral blood flow recovery.Biomedical optics express · 2024Article
- Review
- Depth-selective method for time-domain diffuse reflectance measurements: validation study of the dual subtraction technique.Biomedical optics express · 2023Article
- Two-layered blood-lipid phantom and method to determine absorption and oxygenation employing changes in moments of DTOFs.Biomedical optics express · 2023Article
- Lock-in functional near-infrared spectroscopy for measurement of the haemodynamic brain response.Biomedical optics express · 2022Article
- Time-domain NIRS system based on supercontinuum light source and multi-wavelength detection: validation for tissue oxygenation studies.Biomedical optics express · 2021Article
- Depth-selective data analysis for time-domain fNIRS: moments vs. time windows.Biomedical optics express · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-domain optical brain imaging techniques introduce a number of different measurands for analyzing absorption changes located deep in the tissue, complicated by superficial absorption changes and noise. We implement a method that allows analysis, quantitative comparison and performance ranking of measurands under various conditions - including different values of reduced scattering coefficient, thickness of the superficial layer, and source-detector separation. Liquid phantom measurements and Monte Carlo simulations were carried out in two-layered geometry to acquire distributions of times of flight of photons and to calculate the total photon count, mean time of flight, variance, photon counts in time windows and ratios of photon counts in different time windows. Quantitative comparison of performance was based on objective metrics: relative contrast, contrast-to-noise ratio (CNR) and depth selectivity. Moreover, the product of CNR and depth selectivity was used to rank the overall performance and to determine the optimal source-detector separation for each measurand. Variance ranks the highest under all considered conditions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.