ArticleBiomedical optics express2020
Depth-selective data analysis for time-domain fNIRS: moments vs. time windows.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Change in brain asymmetry reflects level of acute alcohol intoxication and impacts on inhibitory control.Scientific reports · 2023Trial
- Weighting scheme for robust depth normalization in reflectance time-domain diffuse optical tomography.Journal of biomedical optics · 2026Article
- Sensitivity factors for diffuse optics - derivation of equations for finite changes.Biomedical optics express · 2026Article
- A compact time-domain diffuse optical tomography system for cortical neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- How the heterogeneity of the severely injured brain affects hybrid diffuse optical signals: case examples and guidelines.Neurophotonics · 2024Article
- Phase-based structured interrogation frequency-domain near-infrared spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Reliability of brain metrics derived from a Time-Domain Functional Near-Infrared Spectroscopy System.Scientific reports · 2024Article
- Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review.Journal of innovative optical health sciences · 2024Article
- Depth-selective method for time-domain diffuse reflectance measurements: validation study of the dual subtraction technique.Biomedical optics express · 2023Article
- Imaging inside highly scattering media using hybrid deep learning and analytical algorithm.Journal of biophotonics · 2023Article
- Measuring acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans using TD-fNIRS.Scientific reports · 2023Article
- Two-layered blood-lipid phantom and method to determine absorption and oxygenation employing changes in moments of DTOFs.Biomedical optics express · 2023Article
- Novel data types for frequency-domain diffuse optical spectroscopy and imaging of tissues: characterization of sensitivity and contrast-to-noise ratio for absorption perturbations.Biomedical optics express · 2023Article
- How much do time-domain functional near-infrared spectroscopy (fNIRS) moments improve estimation of brain activity over traditional fNIRS?Neurophotonics · 2023Article
- Dissociated coupling between cerebral oxygen metabolism and perfusion in the prefrontal cortex during exercise: a NIRS study.Frontiers in physiology · 2023Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Lock-in functional near-infrared spectroscopy for measurement of the haemodynamic brain response.Biomedical optics express · 2022Article
- Reconstruction of optical coefficients in turbid media using time-resolved reflectance and calibration-free instrument response functions.Biomedical optics express · 2022Article
- Kernel Flow: a high channel count scalable time-domain functional near-infrared spectroscopy system.Journal of biomedical optics · 2022Article
- Precision of time-resolved near-infrared spectroscopy-based measurements of cerebral oxygenation in preterm infants.Neurophotonics · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-domain measurements facilitate the elimination of the influence of extracerebral, systemic effects, a key problem in functional near-infrared spectroscopy (fNIRS) of the adult human brain. The analysis of measured time-of-flight distributions of photons often relies on moments or time windows. However, a systematic and quantitative characterization of the performance of these measurands is still lacking. Based on perturbation simulations for small localized absorption changes, we compared spatial sensitivity profiles and depth selectivity for moments (integral, mean time of flight and variance), photon counts in time windows and their ratios for different time windows. The influence of the instrument response function (IRF) was investigated for all measurands and for various source-detector separations. Variance exhibits the highest depth selectivity among the moments. Ratios of photon counts in different late time windows can achieve even higher selectivity. An advantage of moments is their robustness against the shape of the IRF and instrumental drifts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.