ArticleBiomedical optics express2020
Photoacoustic visualization of the fluence rate dependence of photodynamic therapy.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Label-Free Hemodynamic Mapping via Ultrafast Power Doppler-Enhanced Photoacoustic Imaging reveals early therapy-induced functional changes in the tumor.bioRxiv : the preprint server for biology · 2025Article
- Heterogeneous tumor blood oxygenation dynamics during phototherapy deciphered with real-time label-free photoacoustic imaging.NPJ acoustics · 2025Article
- In vivo, online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound-guided photoacoustic imaging.bioRxiv : the preprint server for biology · 2024Article
- Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review.Journal of biomedical optics · 2024Review
- Multi-level optical angiography for photodynamic therapy.Biomedical optics express · 2023Article
- Achieving depth-independent lateral resolution in AR-PAM using the synthetic-aperture focusing technique.Photoacoustics · 2022Review
- Background-suppressed tumor-targeted photoacoustic imaging using bacterial carriers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Novel Water-Soluble Chlorin-Based Photosensitizer for Low-Fluence Photodynamic Therapy.ACS pharmacology & translational science · 2022Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the fluence rate effect, an essential modulating mechanism of photodynamic therapy (PDT), by using photoacoustic imaging method. To the best of our knowledge, this is the first time that the fluence rate dependence is investigated at a microscopic scale, as opposed to previous studies that are based on tumor growth/necrosis or animal surviving rate. This micro-scale examination enables subtle biological responses, including the vascular damage and the self-healing response, to be studied. Our results reveal the correlations between fluence rate and PDT efficacy/self-healing magnitude, indicating that vascular injuries induced by high fluence rates are more likely to recover and by low fluence rates (≤126 mW/cm
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Registered trials
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