Evidence map›Paper›PMID 32923034›Full record

ArticleBiomedical optics express2020

Model-based evaluation of the microhemodynamic effects of PEGylated HBOC molecules in the rat brain cortex: a laser speckle imaging study.

István Portörő, Péter Mukli, László Kocsis, Péter Hermán, Dario Caccia, Michele Perrella, Andrea Mozzarelli, Luca Ronda, Domokos Mathe, Andras Eke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. AnFrontiers in bioengineering and biotechnology · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

István PortörőInstitute of Translational Medicine, Semmelweis University, Hungary.
Péter MukliInstitute of Translational Medicine, Semmelweis University, Hungary.
László KocsisInstitute of Translational Medicine, Semmelweis University, Hungary.
Péter HermánDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT 06520, USA.
Dario CacciaDepartment of Biomedical Science and Technology, University of Milan, Italy.
Michele PerrellaDepartment of Biomedical Science and Technology, University of Milan, Italy.
Andrea MozzarelliDepartment of Food and Drug, University of Parma, Italy.
Luca RondaInstitute of Biophysics, National Research Council, Pisa, Italy.
Domokos MatheCROmed Research and Service Centers Ltd., Budapest, Hungary.
Andras EkeInstitute of Translational Medicine, Semmelweis University, Hungary.
Semmelweis University · HUUniversity of Milan · ITNational Research Council · ITUniversity of Parma · ITYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Hemoglobin-based oxygen carriers (HBOCs) were developed with the aim of substituting transfusions in emergency events. However, they exhibit adverse events, such as nitric oxide (NO) scavenging, vasoactivity, enhanced platelet aggregation, presently hampering their clinical application. The impact of two prototypical PEGylated HBOCs, Euro-PEG-Hb and PEG-HbO

Identifiers

PMID32923034
PMCPMC7449705
OpenAlexW3023071019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.