ArticleBiomedical optics express2020
Terahertz spectroscopic diagnosis of early blast-induced traumatic brain injury in rats.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Diagnostic accuracy of blast-induced traumatic brain injury: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- All-fibre-coupled terahertz single-pixel imaging for biomedical applications.Nature communications · 2026Article
- A new horizon for neuroscience: terahertz biotechnology in brain research.Neural regeneration research · 2025Article
- Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer's Neuropathology in the APPNeuroscience bulletin · 2024Article
- High-sensitivity THz-ATR imaging of cerebral ischemia in a rat model.Biomedical optics express · 2024Article
- Physics-assisted machine learning for THz time-domain spectroscopy: sensing leaf wetness.Scientific reports · 2024Article
- High resolution terahertz ATR frequency-domain spectroscopy for monitoring spinal cord injury in rats.Biomedical optics express · 2024Article
- Biomedical application of terahertz imaging technology: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
- Serum-based Raman spectroscopic diagnosis of blast-induced brain injury in a rat model.Biomedical optics express · 2023Article
- Discovering Glioma Tissue through Its Biomarkers' Detection in Blood by Raman Spectroscopy and Machine Learning.Pharmaceutics · 2023Article
- Terahertz time-domain attenuated total reflection spectroscopy integrated with a microfluidic chip.Frontiers in bioengineering and biotechnology · 2023Article
- Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury.IEEE reviews in biomedical engineering · 2023Review
- Measurement of tissue optical properties in a wide spectral range: a review [Invited].Biomedical optics express · 2023Review
- Low-Frequency Vibrational Spectroscopy Characteristic of Pharmaceutical Carbamazepine Co-Crystals with Nicotinamide and Saccharin.Sensors (Basel, Switzerland) · 2022Article
- Temperature dependent terahertz spectroscopy and imaging of orthotopic brain gliomas in mouse models.Biomedical optics express · 2022Article
- Advances of terahertz technology in neuroscience: Current status and a future perspective.iScience · 2021Review
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
- Machine Learning Techniques for THz Imaging and Time-Domain Spectroscopy.Sensors (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early diagnosis of blast-induced traumatic brain injury (bTBI) is of great clinical significance for prognostication and treatment. Here, we report a new strategy for early bTBI diagnosis through serum and cerebrospinal fluid (CSF) based on terahertz time-domain spectroscopy (THz-TDS). The spectral differences of serum and CSF for different degrees of experimental bTBI in rats have been demonstrated in the early period. In addition, the THz spectra of total protein in the hypothalamus and hippocampus were investigated at different time points after blast exposure, which both showed clear differences with time increasing compared with that in the normal brain. This might help to explain the neurological symptoms caused by bTBI. Moreover, based on the THz absorption spectra of serum and CSF, the principal component analysis and machine learning algorithms were performed to automatically identify the degree of bTBI. The highest diagnostic accuracy was up to 95.5%. It is suggested that this method has potential as an alternative method for high-sensitive, rapid, label-free, economical and early diagnosis of bTBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.