Evidence map›Paper›PMID 32923009›Full record

ArticleJournal of pharmaceutical analysis2020

TGA/Chemometrics addressing innovative preparation strategies for functionalized carbon nanotubes.

Roberta Risoluti, Giuseppina Gullifa, Elena Carcassi, Andrea Masotti, Stefano Materazzi

Open access · goldAbstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Roberta RisolutiDepartment of Chemistry, "Sapienza", University of Rome, p.le A.Moro 5, 00185, Rome, Italy.
Giuseppina GullifaDepartment of Chemistry, "Sapienza", University of Rome, p.le A.Moro 5, 00185, Rome, Italy.
Elena CarcassiDepartment of Chemistry, "Sapienza", University of Rome, p.le A.Moro 5, 00185, Rome, Italy.
Andrea MasottiBambino Gesù Children's Hospital, IRCCS, Research Laboratories, v.le di San Paolo 15, 00146, Rome, Italy.
Stefano MaterazziDepartment of Chemistry, "Sapienza", University of Rome, p.le A.Moro 5, 00185, Rome, Italy.
Sapienza University of Rome · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, functionalized carbon nanotubes (CNTs) using two polyamine polymers, polyethyleneimine (PEI) and polyamidoamine dendrimer (PAMAM), were investigated by thermal analysis in order to address preparation strategies to obtain low cytotoxic compounds with the ability to conjugate microRNAs and, at the same time, to transfect efficiently endothelial cells. Thermogravimetric analysis (TGA) was coupled to chemometrics as a novel analytical strategy to characterize functionalized CNTs from different preparation conditions. In particular, two starting materials were considered: very small CNTs and carboxylated CNTs (CNT-COOH) in order to examine the affinity with polymers. Chemometrics permitted to compare results from TGA and to investigate the effect of a number of factors affecting the synthesis of coated nanotubes including a different amount of involved polymer and the time required for the suspension for a satisfactory and reproducible preparation procedure. The results demonstrated the effectiveness of TGA as a tool able to address synthesis of coated CNTs to be employed as efficient drug delivery vectors in biomedical applications.

Indexed as

Carbon nanotubesChemometricsPolyamidoamine dendrimer (PAMAM)Polyethyleneimine (PEI)Thermogravimetry

Identifiers

PMID32923009
PMCPMC7474104
OpenAlexW3007359345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.