Evidence map›Paper›PMID 32922653›Full record

ArticleOxidative medicine and cellular longevity2020

Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway.

Chao Huang, Wenbo Zhang, Aijun Sun, Xi Zhang, Jinping Guo, Ruijuan Ji, Liang Qiao, Xuejun Sun, Dongbao Zhao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. The essential role of adenine nucleotide translocase 4 on male reproductive function in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chao HuangDepartment of Anatomy, Institute of Biomedical Engineering, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-5664-0937
Wenbo ZhangDepartment of Rheumatology and Immunology, Changhai Hospital Affiliated to the Naval Medical University, Shanghai 200003, China.ORCID https://orcid.org/0000-0002-8456-9717
Aijun SunDepartment of Anatomy, Institute of Biomedical Engineering, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-1137-4476
Xi ZhangDepartment of Anatomy, Institute of Biomedical Engineering, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-3726-1963
Jinping GuoDepartment of Anatomy, Institute of Biomedical Engineering, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-4315-1784
Ruijuan JiDepartment of Anatomy, Institute of Biomedical Engineering, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-3968-6110
Liang QiaoDepartment of Anatomy, Institute of Biomedical Engineering, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-3963-613X
Xuejun SunDepartment of Navy Aeromedicine, Naval Medical University, #800 Xiangyin Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-2387-5531
Dongbao ZhaoDepartment of Rheumatology and Immunology, Changhai Hospital Affiliated to the Naval Medical University, Shanghai 200003, China.ORCID https://orcid.org/0000-0002-3785-3643
Second Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study is aimed at investigating the anti-inflammatory, antioxidative, and antiapoptotic effects of methane on lipopolysaccharide- (LPS-) induced acute orchitis and its potential mechanisms.

methodsAdult male rats were intraperitoneally (i.p.) injected with methane-rich saline (MS, 20 mL/kg) following LPS (5 mg/kg, i.p.). The survival rate was assessed every 12 h until 72 h after LPS induction, and surviving rats were sacrificed for further detection. The wet/dry (

resultsIt was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. Additionally, methane suppressed and promoted the production of pro- and anti-inflammatory cytokines, respectively. Furthermore, methane significantly increased SOD levels, decreased MDA levels, and decreased testicular expression of PK2 and PKR1. Therefore, methane exerts therapeutic effects on acute orchitis and might be a new and convenient strategy for the treatment of inflammation-related testicular diseases.

Indexed as

ApoptosisAnimalsAnti-Inflammatory AgentsAntioxidantsCytokinesGastrointestinal HormonesLipopolysaccharidesMaleMalondialdehydeMethaneNeuropeptidesOrchitisRats, Sprague-DawleyReceptors, G-Protein-CoupledReceptors, PeptideSignal TransductionAnti-Inflammatory AgentsAntioxidantsCytokinesGastrointestinal HormonesLipopolysaccharidesMalondialdehydeMethaneNeuropeptidesProk2 protein, ratprokineticin receptor 2, ratReceptors, G-Protein-CoupledReceptors, Peptide

Identifiers

PMID32922653
PMCPMC7453259
OpenAlexW3052266462

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.