SKA1 expression in oral squamous cell carcinoma and its relationship to P53 and clinicopathologic features.

Lijuan Zhao, Bin Zhang, Kun Li, Peng Sun

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 54% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy.Molecular oncology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lijuan ZhaoDepartment of Oral and Maxillofacial Surgery, Yantai Stomatological Hospital Affiliated to Binzhou Medical College Yantai 264001, China.

Bin ZhangDepartment of Oral and Maxillofacial Surgery, Liaocheng People's Hospital Affiliated to Taishan Medical University Liaocheng 252000, China.

Kun LiDepartment of Orthodontics, Yantai Stomatological Hospital Affiliated to Binzhou Medical College Yantai 264001, China.

Peng SunDepartment of Orthodontics, Yantai Stomatological Hospital Affiliated to Binzhou Medical College Yantai 264001, China.

Binzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, 57 paraffin-embedded tissue specimens from patients with oral squamous cell carcinoma (OSCC) were collected and analyzed. Spindle and kinetochore-associated complex subunit 1 (SKA1) and P53 protein expression in selected samples was detected by immunohistochemistry. The positive expression rate of SKA1 and P53 was significantly higher in oral squamous cell carcinoma tissues than in normal controls. The expression of SKA1 protein was significantly associated with tumor-node-metastasis (TNM) stage, and p53 expression was significantly correlated with pathologic differentiation grade in oral squamous cell carcinoma tissues. There was a significant correlation between SKA1 and p53 protein expression in oral squamous cell carcinoma tissues. Our results indicate that the SKA1 gene might be involved in the development of oral squamous cell carcinoma and might predict its prognosis. SKA1 is expected to be a new molecular target for oral squamous cell carcinoma.

Indexed as

oral squamous cell carcinomaP53prognosticSpindle and kinetochore-associated complex subunit 1

Identifiers

PMID32922606

PMCPMC7476955

OpenAlexW3086707433

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.