ArticleBiomicrofluidics2020
Complex coacervates as artificial membraneless organelles and protocells.
Article in Biomicrofluidics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery.Bioactive materials · 2025Review
- Peptide Coacervates Can Protect Sequestered Oligonucleotides from Nucleases and Release Them for Transcription and Translation.Biomacromolecules · 2025Article
- The Possible Crystallization Process in the Origin of Bacteria, Archaea, Viruses, and Mobile Elements.Biology · 2024Article
- Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications.ACS biomaterials science & engineering · 2024Review
- Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Review
- Designing negative feedback loops in enzymatic coacervate droplets.Chemical science · 2023Article
- Capturing coacervate formation and protein partition by molecular dynamics simulation.Chemical science · 2023Article
- Prebiotic Chemistry Experiments Using Microfluidic Devices.Life (Basel, Switzerland) · 2022Review
- Lipid coated protein condensates as stable protocells with selective uptake abilities for biomolecules.Chemical science · 2022Article
- Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications.International journal of nanomedicine · 2022Review
- Active coacervate droplets are protocells that grow and resist Ostwald ripening.Nature communications · 2021Article
- Temperature-Responsive Peptide-Nucleotide Coacervates.The journal of physical chemistry. B · 2021Article
- Recent developments in microfluidic synthesis of artificial cell-like polymersomes and liposomes for functional bioreactors.Biomicrofluidics · 2021Article
- Connecting primitive phase separation to biotechnology, synthetic biology, and engineering.Journal of biosciences · 2021Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex coacervates are water droplets dispersed in water, which are formed by spontaneous liquid-liquid phase separation of an aqueous solution of two oppositely charged polyelectrolytes. Similar to the membraneless organelles that exist in biological cells, complex coacervate droplets are membraneless and have a myriad of features including easy formation, high viscosity, selective encapsulation of biomolecules, and dynamic behaviors in response to environmental stimuli, which make coacervates an excellent option for constructing artificial membraneless organelles. In this article, I first summarize recent advances in artificial compartments that are built from coacervates and their response to changes in the surrounding environment and then show the advantages of microfluidic techniques in the preparation of monodisperse coacervates and encapsulation of coacervates in droplets and liposomes to construct complex cell-like compartments, and finally discuss the future challenges of such membraneless aqueous compartments in cell mimics and origin of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.