Evidence map›Paper›PMID 32922542›Full record

ArticleJournal of Cancer2020

The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas.

Nicusor Iftimia, Aditi Sahu, Miguel Cordova, Gopi Maguluri, Melissa Gill, Christi Alessi-Fox, Salvador Gonzalez, Cristian Navarrete-Dechent, Ashfaq Marghoob, Chih-Shan J Chen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Nicusor IftimiaPhysical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, MA, USA.
Aditi SahuDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Miguel CordovaDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gopi MaguluriPhysical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, MA, USA.
Melissa GillDepartment of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Christi Alessi-FoxCaliber Imaging and Diagnostics, Rochester, NY, USA.
Salvador GonzalezAlcala University, Madrid, Spain.
Cristian Navarrete-DechentPontificia Universidad Catolica De Chile, Santiago, Chile.
Ashfaq MarghoobDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chih-Shan J ChenDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Milind RajadhyakshaDermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USCaliber Imaging and Diagnostics (United States) · USPhysical Sciences (United States) · USPontificia Universidad Católica de Chile · CLSUNY Downstate Health Sciences University · USUniversidad de Alcalá · ES

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Peri-operative confocal imaging-guided laser ablation of basal cell carcinomasR01EB020029 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI RAJADHYAKSHA, MILIND · 2015 to 2018
$2.2M
Multimodal Optical Probe for Skin Cancer Detection and Therapy GuidanceR44CA240040 · NCI · PHYSICAL SCIENCES, INC · PI IFTIMIA, NICUSOR · 2019 to 2021
$1.7M
NCI NIH HHS P30 CA008748NCI NIH HHS R44 CA240040NIBIB NIH HHS R01 EB020029
6 · The paper itself

Abstract

The increasing rate of incidence and prevalence of basal cell carcinomas (BCCs) worldwide, combined with the morbidity associated with conventional surgical treatment has led to the development and use of alternative minimally invasive non-surgical treatments. Biopsy and pathology are used to guide BCC diagnosis and assess margins and subtypes, which then guide the decision and choice of surgical or non-surgical treatment. However, alternatively, a noninvasive optical approach based on combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging may be used. Optical imaging may be used to guide diagnosis and margin assessment at the bedside, and potentially facilitate non-surgical management, along with long-term monitoring of treatment response. Noninvasive imaging may also complement minimally invasive treatments and help further reduce morbidity. In this paper, we highlight the current state of an integrated RCM/OCT imaging approach for diagnosis and triage of BCCs, as well as for assessing margins, which therefore may be ultimately used for guiding therapy.

Indexed as

basal cell carcinomasinvasive non-surgical treatmentsoptical coherence tomographyreflectance confocal microscopy

Identifiers

PMID32922542
PMCPMC7477415
OpenAlexW3084343169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.