ArticleIranian journal of pharmaceutical research : IJPR2020
Erythromycin Releasing PVA/sucrose and PVA/honey Hydrogels as Wound Dressings with Antibacterial Activity and Enhanced Bio-adhesion.
Article in Iranian journal of pharmaceutical research : IJPR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Engineering Robust, Porous Guar Gum Hydrogels by One-Step Mild Synthesis: Impact of Porogen Choice on Rheology and Sustained Gastroretentive Amoxicillin Delivery.Gels (Basel, Switzerland) · 2025Article
- Kelulut Honey-Incorporated Hybrid Gelatin-PVA Hydrogel for Wound Healing: Fabrication and In Vitro Characterization.Polymers · 2025Article
- Composite HPMC-Gelatin Films Loaded with Cameroonian and Manuka Honeys Show Antibacterial and Functional Wound Dressing Properties.Gels (Basel, Switzerland) · 2025Article
- Controlled Release of Hydrophilic Active Agent from Textile Using Crosslinked Polyvinyl Alcohol Coatings.Journal of functional biomaterials · 2025Article
- Advances in arthropod-inspired bionic materials for wound healing.Materials today. Bio · 2024Review
- Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics.Saudi journal of biological sciences · 2024Review
- Antibacterial and Anti-Inflammatory Polysaccharide fromMolecules (Basel, Switzerland) · 2024Article
- Hydrogel Breakthroughs in Biomedicine: Recent Advances and Implications.Current pharmaceutical biotechnology · 2024Review
- Exploring the potential of a polyvinyl alcohol/chitosan-based nanofibrous matrix for erythromycin delivery: fabrication,RSC advances · 2023Article
- Antimicrobial Natural Hydrogels in Biomedicine: Properties, Applications, and Challenges-A Concise Review.International journal of molecular sciences · 2023Review
- Erythromycin Formulations-A Journey to Advanced Drug Delivery.Pharmaceutics · 2022Review
- Recent Advances in Honey-Based Nanoparticles for Wound Dressing: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- A Review on Recent Progress of Stingless Bee Honey and Its Hydrogel-Based Compound for Wound Care Management.Molecules (Basel, Switzerland) · 2022Review
- Physically Crosslinked Chitosan/PVA Hydrogels Containing Honey and Allantoin with Long-Term Biocompatibility for Skin Wound Repair: An In Vitro and In Vivo Study.Journal of functional biomaterials · 2021Article
- Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview.Materials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study deals with preparation and characterization of thermally crosslinked PVA-based hydrogels containing honey and sucrose for the purpose of erythromycin delivery. The hydrogels have been characterized and compared by scanning electron microscopy, Fourier transform infrared spectroscopy, and bio-adhesion tests. Swelling measurements showed that addition of sucrose and honey decreased the equilibrium swelling of the hydrogels. Results of release studies showed that the amount of erythromycin, released at the early hours was higher for PVA/sucrose and PVA/honey hydrogels compared to PVA hydrogel while the drug released at later times was highly reduced for PVA/honey hydrogel. Both Peppas-Sahlin and Korsmeyer-Peppas models fitted well to the release data. Fitting Peppas-Sahlin model to the release data showed that at the initial times, release of drug from the hydrogel network was mainly governed by Fickian mechanism; however, at later times the drug is dominantly released by relaxational mechanism due to swelling of the network,. Addition of honey improved the bio-adhesion of PVA/honey hydrogel as compared to PVA/sucrose and pure PVA hydrogel. Results of antibacterial tests showed growth inhibitory action of erythromycin-loaded PVA hydrogels against
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