Evidence map›Paper›PMID 32922350›Full record

ArticleFrontiers in neurology2020

Hemodynamics of Prefrontal Cortex in Ornithine Transcarbamylase Deficiency: A Twin Case Study.

Afrouz A Anderson, Andrea Gropman, Cynthia Le Mons, Constantine A Stratakis, Amir H Gandjbakhche

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The nano delivery systems and applications of mRNA.European journal of medicinal chemistry · 2022
    Review
  4. Neuromonitoring in Rare Disorders of Metabolism.The Yale journal of biology and medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Afrouz A AndersonNational Institutes of Health (NIH), National Institute of Child Health and Human Development, Bethesda, MD, United States.
Andrea GropmanChildren's National Medical Center, Division of Neurogenetics and Neurodevelopmental Pediatrics, Washington, DC, United States.
Cynthia Le MonsNational Urea Cycle Disorders Foundation, Pasadena, CA, United States.
Constantine A StratakisNational Institutes of Health (NIH), National Institute of Child Health and Human Development, Bethesda, MD, United States.
Amir H GandjbakhcheNational Institutes of Health (NIH), National Institute of Child Health and Human Development, Bethesda, MD, United States.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USChildren's National · USNational Institutes of Health · USNational Urea Cycle Disorders Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ornithine transcarbamylase deficiency (OTCD) is the most common form of urea cycle disorder characterized by the presence of hyperammonemia (HA). In patients with OTCD, HA is known to cause impairments in domains of executive function and working memory. Monitoring OTCD progression and investigating neurocognitive biomarkers can, therefore, become critical in understanding the underlying brain function in a population with OTCD. We used functional near infrared spectroscopy (fNIRS) to examine the hemodynamics of prefrontal cortex (PFC) in a fraternal twin with and without OTCD. fNIRS is a non-invasive and wearable optical technology that can be used to assess cortical hemodynamics in a realistic clinical setting. We quantified the hemodynamic variations in total-hemoglobin as assessed by fNIRS while subjects performed the

Indexed as

cerebral autoregulationfNIRSfunctional connectivityfunctional near infrared spectroscopyOrnithine transcarbamylase deficiencyurea cycle disorderswavelet coherence

Identifiers

PMID32922350
PMCPMC7456944
OpenAlexW3049559313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.