ArticleFrontiers in physiology2020
Surfactant-Mediated Airway and Acinar Interactions in a Multi-Scale Model of a Healthy Lung.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026Review
- Predictions of Atelectasis-Induced Microvolutrauma: A Key Pathway to Ventilator-Induced Lung Injury.Journal of biomechanical engineering · 2025Article
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Study on the flow mechanism and frequency characteristics of rales in lower respiratory tract.Biomechanics and modeling in mechanobiology · 2024Article
- Full-lung simulations of mechanically ventilated lungs incorporating recruitment/derecruitment dynamics.Frontiers in network physiology · 2023Article
- Computational lung modelling in respiratory medicine.Journal of the Royal Society, Interface · 2022Review
- Towards a multi-scale computer modeling workflow for simulation of pulmonary ventilation in advanced COVID-19.Computers in biology and medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We present a computational multi-scale model of an adult human lung that combines dynamic surfactant physicochemical interactions and parenchymal tethering between ~16 generations of airways and subtended acini. This model simulates the healthy lung by modeling nonlinear stress distributions from airway/alveolar interdependency. In concert with multi-component surfactant transport processes, this serves to stabilize highly compliant interacting structures. This computational model, with ~10 k degrees of freedom, demonstrates physiological processes in the normal lung such as multi-layer surfactant transport and pressure-volume hysteresis behavior. Furthermore, this model predicts non-equilibrium stress distributions due to compliance mismatches between airway and alveolar structures. This computational model provides a baseline for the exploration of multi-scale interactions of pathological conditions that can further our understanding of disease processes and guide the development of protective ventilation strategies for the treatment of acute respiratory distress syndrome (ARDS).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.