Evidence map›Paper›PMID 32922211›Full record

ReviewThrombosis journal2020

Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory.

M Hardy, T Lecompte, J Douxfils, S Lessire, J M Dogné, B Chatelain, S Testa, I Gouin-Thibault, Y Gruel, R L Medcalf and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Thrombosis journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Colchicine, COVID-19 and hematological parameters: A meta-analysis.Journal of clinical laboratory analysis · 2021
    Pooled it
  2. Guideline
  3. Admission biomarkers and COVID-19 mortality: A retrospective study during Vietnam's pandemic peak.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  4. Review
  5. Review
  6. Lupus anticoagulants as a prospective independent predictor in COVID-19 patients.International journal of laboratory hematology · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Clinical use of thrombin generation assays.Journal of thrombosis and haemostasis : JTH · 2021
    Review
  11. Article
  12. Review
  13. COVID-19-related laboratory coagulation findings.International journal of laboratory hematology · 2021
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

M HardyUniversité catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Hematology Laboratory, Yvoir, Belgium.
T LecompteDépartement de Médecine, Hôpitaux Universitaires de Genève, service d'angiologie et d'hémostase et Faculté de Médecine Geneva Platelet Group (GpG), Université de Genève, Geneva, Suisse Switzerland.
J DouxfilsPharmacy Department, University of Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur, Belgium.
S LessireUniversité catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Anesthesiology Department, Yvoir, Belgium.
J M DognéPharmacy Department, University of Namur, Namur Thrombosis and Hemostasis Center (NTHC), Namur, Belgium.
B ChatelainUniversité catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Hematology Laboratory, Yvoir, Belgium.
S TestaHaemostasis and Thrombosis Center, Cremona Hospital, Cremona, Italy.
I Gouin-ThibaultDépartement d'Hématologie Biologique, INSERM, CIC 1414 (Centre d'Investigation Clinique de Rennes), Université de Rennes, CHU de Rennes, Rennes, France.
Y GruelLaboratoire d'Hématologie-Hémostase, CHRU de Tours, Hôpital Trousseau, Tours, France.
R L MedcalfAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria Australia.
H Ten CateDepartment of Internal Medicine, Cardiovascular Research Institute (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.
G LippiSection of Clinical Biochemistry, University of Verona, Verona, Italy.
F MullierUniversité catholique de Louvain, CHU UCL Namur, Namur Thrombosis and Hemostasis Center (NTHC), Hematology Laboratory, Yvoir, Belgium.ORCID 0000-0001-6947-6099
University of Namur · BECentre Hospitalier Universitaire de Tours · FRInserm · FRIstituti Ospitalieri di Cremona · ITMaastricht University · NLMonash Medical Centre · AUUniversity of Geneva · CHUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is associated with extreme inflammatory response, disordered hemostasis and high thrombotic risk. A high incidence of thromboembolic events has been reported despite thromboprophylaxis, raising the question of a more effective anticoagulation. First-line hemostasis tests such as activated partial thromboplastin time, prothrombin time, fibrinogen and D-dimers are proposed for assessing thrombotic risk and monitoring hemostasis, but are vulnerable to many drawbacks affecting their reliability and clinical relevance. Specialized hemostasis-related tests (soluble fibrin complexes, tests assessing fibrinolytic capacity, viscoelastic tests, thrombin generation) may have an interest to assess the thrombotic risk associated with COVID-19. Another challenge for the hemostasis laboratory is the monitoring of heparin treatment, especially unfractionated heparin in the setting of an extreme inflammatory response. This review aimed at evaluating the role of hemostasis tests in the management of COVID-19 and discussing their main limitations.

Indexed as

AnticoagulationCoagulopathyCOVID-19D-dimersFibrinolysisHemostasisHeparinThrombin generationThrombosisViscoelastic tests

Identifiers

PMID32922211
PMCPMC7474970
OpenAlexW3083163666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.