Evidence map›Paper›PMID 32922011›Full record

ArticleInternational journal of nanomedicine2020

Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC.

Liang Kong, Shi-Meng Zhang, Jia-Hao Chu, Xin-Ze Liu, Lu Zhang, Si-Yu He, Si-Min Yang, Rui-Jun Ju, Xue-Tao Li

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. The anti-cancer activity of Dioscin: an update and future perspective.Medical oncology (Northwood, London, England) · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Liposomes for Tumor Targeted Therapy: A Review.International journal of molecular sciences · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Size-Dependent Antibacterial Immunity ofInternational journal of nanomedicine · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Liang KongSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Shi-Meng ZhangDepartment of Neurology, Linyi People's Hospital, Linyi 276003, People's Republic of China.
Jia-Hao ChuDepartment of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People's Republic of China.
Xin-Ze LiuSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Lu ZhangSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Si-Yu HeSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Si-Min YangDepartment of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People's Republic of China.
Rui-Jun JuDepartment of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People's Republic of China.
Xue-Tao LiSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People's Republic of China.
Liaoning University of Traditional Chinese Medicine · CNBeijing Institute of Petrochemical Technology · CNLinyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse. PURPOSE: The objective of this study was to construct a novel CPP METHODS AND

resultsThe targeting liposomes could be enriched in tumor sites through passive targeting, and the positively charged CPP was exposed and enhanced active targeting via electrostatic adsorption after being hydrolyzed by MMP2 enzymes overexpressed in the tumor microenvironment. We found that CPP

conclusionCPP

Indexed as

Tumor MicroenvironmentA549 CellsAnimalsAntineoplastic AgentsCarcinoma, Non-Small-Cell LungCell DeathCell MovementChickensEndocytosisEpithelial-Mesenchymal TransitionHumansHydrolysisLiposomesLung NeoplasmsMice, Inbred BALB CMice, Nude1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)Antineoplastic AgentsLiposomesPhosphatidylethanolaminesPolyethylene GlycolsVinorelbinedioscinMMP2 enzymesmulti-functional liposomesnon-small cell lung cancertumor microenvironmentvinorelbine

Identifiers

PMID32922011
PMCPMC7457883
OpenAlexW3080128454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.