Evidence map›Paper›PMID 32921989›Full record

Trial reportDrug design, development and therapy2020

Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial.

Bin Qian, Wenting Zheng, Jiawei Shi, Zihan Chen, Yanhua Guo, Yusheng Yao

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bin QianDepartment of Anesthesiology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, People's Republic of China.
Wenting ZhengDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Jiawei ShiDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Zihan ChenDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Yanhua GuoDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Yusheng YaoDepartment of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.ORCID 0000-0001-8488-8876
Fujian Medical University · CNFujian University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the efficacy of intranasal dexmedetomidine and dexmedetomidine-ketamine premedication in preschool children undergoing tonsillectomy. PATIENTS AND

methodsWe enrolled 66 children with American Society of Anesthesiologists physical status I or II, aged 3-7 years undergoing tonsillectomy. Patients were randomly allocated to receive intranasal premedication with either dexmedetomidine 2 μg kg

resultsAt 30 min after premedication, the MOAA/S score was lower in Group DK than in Group D patients (median: 1.0, interquartile range [IQR]: 1.0-2.0 vs median: 3.0, IQR: 2.0-3.0;

conclusionIntranasal premedication with a combination of dexmedetomidine and ketamine produced better sedation for pediatric tonsillectomy than dexmedetomidine alone.

Indexed as

Administration, IntranasalAdrenergic alpha-AgonistsChildChild, PreschoolDexmedetomidineDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansHypnotics and SedativesKetamineMalePostoperative PainPreanesthetic MedicationTonsillectomyAdrenergic alpha-AgonistsDexmedetomidineHypnotics and SedativesKetaminemask inductionpediatric anesthesiapreoperative sedation

Identifiers

PMID32921989
PMCPMC7457813
OpenAlexW3081040568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.