Evidence map›Paper›PMID 32921793›Full record

ArticleGenes and immunity2020

Atypical immune phenotype in severe combined immunodeficiency patients with novel mutations in IL2RG and JAK3.

Lior Goldberg, Amos J Simon, Atar Lev, Ortal Barel, Tali Stauber, Vered Kunik, Gideon Rechavi, Raz Somech

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Genes and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lior GoldbergSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.ORCID http://orcid.org/0000-0002-1643-7616
Amos J SimonPediatric Department A, Pediatric Immunology Service, Jeffrey Modell Foundation (JMF) Center, Sheba Medical Center, Tel HaShomer, Israel.
Atar LevPediatric Department A, Pediatric Immunology Service, Jeffrey Modell Foundation (JMF) Center, Sheba Medical Center, Tel HaShomer, Israel.
Ortal BarelSheba Cancer Research Center, Sheba Medical Center, Tel HaShomer, Israel.
Tali StauberSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Vered KunikBioinformatics Consulting, Gat Rimon, Israel.
Gideon RechaviSheba Cancer Research Center, Sheba Medical Center, Tel HaShomer, Israel.
Raz SomechSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. raz.somech@sheba.health.gov.il.ORCID http://orcid.org/0000-0001-6648-9425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the common gamma chain of the interleukin 2 receptor (IL2RG) or the associated downstream signaling enzyme Janus kinase 3 (JAK3) genes are typically characterized by a T cell-negative, B cell-positive, natural killer (NK) cell-negative (T

Indexed as

PhenotypeFemaleHumansInfantInterleukin Receptor Common gamma SubunitJanus Kinase 3MaleMutationPedigreeProtein Conformation, alpha-HelicalSevere Combined ImmunodeficiencyIL2RG protein, humanInterleukin Receptor Common gamma SubunitJAK3 protein, humanJanus Kinase 3

Identifiers

PMID32921793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.