Evidence map›Paper›PMID 32921524›Full record

ArticleTrends in cell biology2020

Caspase 2 and p53 Reunited in Tumor Control.

Giulia Petroni, Ilio Vitale, Lorenzo Galluzzi

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 4 countries.

Giulia PetroniDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Ilio VitaleIIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA; Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA; Université de Paris, Paris, France. Electronic address: deadoc80@gmail.com.
Cornell University · USIstituti di Ricovero e Cura a Carattere Scientifico · ITLander Institute · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells.

Indexed as

NeoplasmsTumor Suppressor Protein p53ApoptosisCaspase 2Cell Cycle CheckpointsDNA Breaks, Double-StrandedDNA DamageHumansProto-Oncogene Proteins c-mdm2Radiation, IonizingCaspase 2Proto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53CDK4/CDK6 inhibitorsdouble-stand DNA breaksionizing radiationMDM2PIDD1type I interferon

Identifiers

PMID32921524
OpenAlexW3085789222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.