Evidence map›Paper›PMID 32921042›Full record

ArticleACS sensors2020

Plasmonic Gold Nanostar-Enhanced Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Molecular Imaging To Evaluate Choroidal Neovascularization.

Van-Phuc Nguyen, Yanxiu Li, Jessica Henry, Wei Zhang, Michael Aaberg, Sydney Jones, Thomas Qian, Xueding Wang, Yannis M Paulus

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Gold Nanoparticles for Retinal Molecular Optical Imaging.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Molecular and cellular imaging of the eye.Biomedical optics express · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Van-Phuc NguyenDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.ORCID 0000-0001-7466-1483
Yanxiu LiDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.
Jessica HenryDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.
Wei ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48105, United States.
Michael AabergDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.
Sydney JonesDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.
Thomas QianDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48105, United States.
Yannis M PaulusDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan 48105, United States.
University of Michigan · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Real-time In Vivo Visualization of the Molecular Processes in Choroidal NeovascularizationK08EY027458 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAULUS, YANNIS MANTAS · 2018 to 2021
$898k
NEI NIH HHS K08 EY027458NEI NIH HHS P30 EY007003
6 · The paper itself

Abstract

Although photoacoustic microscopy (PAM) and optical coherence tomography (OCT) allow visualization of the retinal microvasculature, distinguishing early neovascularization from adjacent vessels remains challenging. Herein, gold nanostars (GNSs) functionalized with an RGD peptide were utilized as multimodality contrast agents for both PAM and OCT. GNSs have great absorption and scattering characteristics in the near-infrared region where most vasculature and tissue generates a less intrinsic photoacoustic signal while having a small size, excellent biocompatibility

Indexed as

Choroidal NeovascularizationPhotoacoustic TechniquesAnimalsGoldMicroscopyMolecular ImagingRabbitsTomography, Optical CoherenceGoldchoroidal neovascularizationcontrast agentsgold nanostarsmultimodal molecular imagingoptical coherence tomographyphotoacoustic microscopyphotoacoustic ophthalmoscopy

Identifiers

PMID32921042
PMCPMC8121042
OpenAlexW3086558870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.