ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
What it found
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Who cites it
133 citing papers in PubMed, 166 citations in OpenAlex.
- Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes.JAMA network open · 2023Trial
- Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial.JAMA network open · 2023Trial
- Charting confidence in white matter brain charts: enabling study planning through stability validation.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- SIRT1 in brain aging: molecular mechanisms and therapeutic potential of pharmacological and natural modulators.Biogerontology · 2026Review
- Topography of Juxtaventricular white matter hyperintensities and cognitive associations in Alzheimer's disease: a dual-cohort study.European radiology experimental · 2026Article
- Elevated BrainAGE precedes cognitive impairment and improves prediction of future cognitive decline.medRxiv : the preprint server for health sciences · 2026Article
- Association of Lacunes with Risk Factors, Cognition, and Atrophy: The Multi-Ethnic Study of Atherosclerosis (MESA).medRxiv : the preprint server for health sciences · 2026Article
- Association of sleep duration with Alzheimer's disease and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- Advancing fair and explainable machine learning for neuroimaging dementia pattern classification in multi-racial and multi-ethnic populations.Nature communications · 2026Article
- Charting Cervical Spinal Cord Morphometry Across the Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Batch Effect Correction for Neuroimaging Data with Heterogeneous Spatial Correlations.bioRxiv : the preprint server for biology · 2026Article
- Accelerated brain aging in prolonged grief disorder of later life: Influence of comorbid depression.Journal of affective disorders · 2026Article
- Dense longitudinal neuroimaging reveals individual brain change trajectories.Trends in cognitive sciences · 2026Review
- Cardiovascular Health at Midlife and Alzheimer Disease Biomarkers.medRxiv : the preprint server for health sciences · 2026Article
- Article
- SIRT1 Activators as Geroprotective Agents in Brain Aging: Mechanisms and Therapeutic Potential.Neuromolecular medicine · 2026Review
- Regional growth rates of white matter hyperintensities are associated with beta-amyloid burden.Neurobiology of aging · 2026Article
- Midlife sleep characteristics and Alzheimer's disease biomarkers 20 years later.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multimodal MRI and machine learning for identifying depression in cerebral small vessel disease: a multicenter study.BMC medical imaging · 2026Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 14 institutions in 3 countries.
Funding
Abstract
introductionRelationships between brain atrophy patterns of typical aging and Alzheimer's disease (AD), white matter disease, cognition, and AD neuropathology were investigated via machine learning in a large harmonized magnetic resonance imaging database (11 studies; 10,216 subjects).
methodsThree brain signatures were calculated: Brain-age, AD-like neurodegeneration, and white matter hyperintensities (WMHs). Brain Charts measured and displayed the relationships of these signatures to cognition and molecular biomarkers of AD.
resultsWMHs were associated with advanced brain aging, AD-like atrophy, poorer cognition, and AD neuropathology in mild cognitive impairment (MCI)/AD and cognitively normal (CN) subjects. High WMH volume was associated with brain aging and cognitive decline occurring in an ≈10-year period in CN subjects. WMHs were associated with doubling the likelihood of amyloid beta (Aβ) positivity after age 65. Brain aging, AD-like atrophy, and WMHs were better predictors of cognition than chronological age in MCI/AD. DISCUSSION: A Brain Chart quantifying brain-aging trajectories was established, enabling the systematic evaluation of individuals' brain-aging patterns relative to this large consortium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.