ArticleJournal of clinical laboratory analysis2021
Comparison of antifungal and cytotoxicity activities of titanium dioxide and zinc oxide nanoparticles with amphotericin B against different Candida species: In vitro evaluation.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 60 citations in OpenAlex.
- Evaluation of the biological activities of Bacillus cereus-synthesized titanium dioxide nanoparticles.Applied microbiology and biotechnology · 2026Article
- Bridging Gaps in Fungal Keratitis Management: Novel Diagnostics, Drug Delivery Systems, and Gene Therapies.AAPS PharmSciTech · 2026Review
- Zinc oxide nanoparticles againstFrontiers in antibiotics · 2026Review
- Antifungal effect of titanium oxide nanoparticles onFrontiers in cellular and infection microbiology · 2025Article
- Intensification of Invasive Fungal Infections and Exploration of Effective Antifungal Drug Delivery Formulations: A Detailed Review.Infectious disorders drug targets · 2025Review
- Antibacterial, antifungal, and antibiofilm activities of biogenic zinc nanoparticles against pathogenic microorganisms.Frontiers in cellular and infection microbiology · 2025Article
- Antibiofilm Activity of PDMS/TiOACS omega · 2024Article
- TiOFood science & nutrition · 2024Article
- Phytochemical profile and antimicrobial activity ofHeliyon · 2024Article
- Synthesis of nanoparticles using Trichoderma Harzianum, characterization, antifungal activity and impact on Plant Growth promoting Bacteria.World journal of microbiology & biotechnology · 2024Article
- Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment.Heliyon · 2024Article
- Development of thermosensitive hydrogel of Amphotericin-B and Lactoferrin combination-loaded PLGA-PEG-PEI nanoparticles for potential eradication of ocular fungal infections:International journal of pharmaceutics: X · 2023Article
- Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B.Antibiotics (Basel, Switzerland) · 2023Review
- Antifungal Effect of Nanoparticles against COVID-19 Linked Black Fungus: A Perspective on Biomedical Applications.International journal of molecular sciences · 2022Review
- Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis.International journal of molecular sciences · 2022Review
- Screening, characterisation and bioactivities of green fabricated TiOEnvironmental science and pollution research international · 2022Article
- Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds.Antibiotics (Basel, Switzerland) · 2022Article
- Characterization of nanomaterials synthesized from Spirulina platensis extract and their potential antifungal activity.PloS one · 2022Article
- Diagnostic value of serum human Galactomannan aspergillus antigen and 1,3-beta-D-glucan in immunocompromised patient suspected fungal infection.Journal of clinical laboratory analysis · 2021Article
- Comparison of antifungal and cytotoxicity activities of titanium dioxide and zinc oxide nanoparticles with amphotericin B against different Candida species: In vitro evaluation.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCandida species are known to cause serious fungal infections that produce cutaneous, mucosal, and systemic infections. Nowadays, mortality and morbidity candidiasis in immunocompromised patients have increased. Nanotechnology is a new world-known technology and includes particles ranging from about 1 to 100 nanometers. The purpose of this study was to evaluate the antifungal and cytotoxicity activities of titanium dioxide nanoparticles (TiO2-NPs) and zinc oxide nanoparticles (ZnO-NPs) compared to amphotericin B (AmB) on different Candida spp in in vitro conditions.
methodsIn the present study, susceptibility of different Candida species to TiO2-NPs and ZnO-NPs compared to AmB was determined by broth microdilution (BMD) and agar well diffusion methods. Cytotoxicity of TiO2-NPs and ZnO-NPs and amphotericin B was measured by MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-Diphenyltetrazolium Bromide) assay.
resultsThe results indicated that the TiO2-NPs and ZnO-NPs showed antifungal activities against pathogenic Candida spp. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of TiO2-NP ranges against Candida spp. were 128-256 µg/mL and 256-512 µg/mL, respectively. The MIC and MFC values of ZnO-NPs were 64-128 µg/mL and 256-512 µg/mL, respectively. However, MICs and MFCs of AmB were 8-16 µg/mL and 16-32 µg/mL, respectively. The MTT assay results showed that the CC50% belonged to ZnO-NPs 706.2 μg/mL, for TiO2-NPs 862.1 μg/mL, and for AmB 70.19 μg/mL, respectively.
conclusionOur findings showed that TiO2-NPs and ZnO-NPs had antifungal effects against all Candida species, yet the antifungal properties of TiO2-NPs and ZnO-NPs were significantly less than those of AmB. The CC50% of AmB was significantly lower than ZnO-NPs and TiO2-NPs.
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