Evidence map›Paper›PMID 32920764›Full record

ReviewCurrent HIV/AIDS reports2020

A Review of HIV Pre-exposure Prophylaxis Streamlining Strategies.

Aaron J Siegler, Kevin Steehler, Jessica M Sales, Douglas S Krakower

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron J SieglerDepartment of Behavioral Sciences and Health Education, Emory University, Rollins School of Public Health, Atlanta, GA, USA. asiegle@emory.edu.ORCID 0000-0001-5553-7540
Kevin SteehlerDepartment of Behavioral Sciences and Health Education, Emory University, Rollins School of Public Health, Atlanta, GA, USA.
Jessica M SalesDepartment of Behavioral Sciences and Health Education, Emory University, Rollins School of Public Health, Atlanta, GA, USA.
Douglas S KrakowerDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, The Fenway Institute, Fenway Health, Department of Population Medicine, Harvard Medical School, Boston, MA, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Population-based survey of SARS-CoV-2 infection and immune responseR01AI143875 · NIAID · EMORY UNIVERSITY · PI SIEGLER, AARON JULIUS, SULLIVAN, PATRICK SEAN · 2019 to 2023
$9.2M
Making it last: A randomized, controlled trial of a home care system to promote persistence in PrEP careR01MH114692 · NIMH · EMORY UNIVERSITY · PI MAYER, KENNETH H, SIEGLER, AARON JULIUS · 2017 to 2021
$5.8M
NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI143875NIMH NIH HHS R01 MH114692
6 · The paper itself

Abstract

purpose of reviewStandard care for HIV pre-exposure prophylaxis (PrEP) in the USA creates substantial burdens for patients, clinicians, and the healthcare system; to optimize uptake, there is a need for innovative strategies to streamline its provision. RECENT

findingsOur review, structured by the expanded chronic care model, identified eleven promising strategies to streamline PrEP care. Approaches ranged widely in mechanism of action. Using text messages to support care was the only strategy with clinical trial evidence supporting its use. Other modalities such as patient navigation, telemedicine PrEP models, alternate dosing availability, same-day prescription, and provider training have promising pilot or associational data and seem likely to lower barriers to entering into or remaining in care. Many of the strategies have established success in related domains such as HIV care, meriting consideration in evaluating their use for PrEP. Making PrEP care less burdensome will be an important part of bringing it to scale. Text message interventions have proven efficacy and merit broad adoption. Encouraging preliminary evidence for other strategies indicates the importance of building a stronger evidence base to clarify the effect of each strategy. Ongoing development of an evidence base should not delay the use of these promising strategies; instead, it calls for careful consideration for how each program may best match its environment to facilitate PrEP prescribing and use.

Indexed as

Anti-HIV AgentsHIV InfectionsHomosexuality, MaleHumansMalePatient NavigationPre-Exposure ProphylaxisSelf-Help GroupsSexual and Gender MinoritiesTelemedicineText MessagingAnti-HIV AgentsChronic care modelmHealthPrEPTelemedicine

Identifiers

PMID32920764
PMCPMC7671972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.