ArticleMikrochimica acta2020
A paper-based device for the colorimetric determination of ammonia and carbon dioxide using thiomalic acid and maltol functionalized silver nanoparticles: application to the enzymatic determination of urea in saliva and blood.
Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- pH-Inhibited Fenton etching of gold nanobipyramids: a multicolor approach for enhanced urea detection.Microsystems & nanoengineering · 2025Article
- Paper-Based Vertical Flow Assays for in Vitro Diagnostics and Environmental Monitoring.ACS sensors · 2025Review
- Article
- Monitoring saliva compositions for non-invasive detection of diabetes using a colorimetric-based multiple sensor.Scientific reports · 2023Article
- An origami-based colorimetric sensor for detection of hydrogen peroxide and glucose using sericin capped silver nanoparticles.Scientific reports · 2023Article
- Visual diagnosis of COVID-19 disease based on serum metabolites using a paper-based electronic tongue.Analytica chimica acta · 2022Article
- Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations-A Review.Biosensors · 2021Review
- Origami paper analytical assay based on metal complex sensor for rapid determination of blood cyanide concentration in fire survivors.Scientific reports · 2021Article
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Abstract
A colorimetric assay was developed which has the capability of determining urea in biological samples. It is an origami paper-based sensor consisting of silver nanoparticles that were synthesized by using two different capping agents: thiomalic acid and maltol. The function of the assay relied on hydrolysis of urea to ammonia and carbon dioxide in the presence of urease. The products interacted with nanoparticles which caused aggregation. Interestingly, thiomalic acid capped with silver nanoparticles were selective to ammonia, and the other nanoparticles synthesized by maltol responded to carbon dioxide. These interactions turned the color of nanoparticles from yellow to brown and red, respectively. The resulting colorations were captured by a floatable scanner. A routine image analysis software was utilized to provide the response of the assays. The method was applied to individually determine ammonia, carbon dioxide, and urea. The linear range was 0.06 mg.dL
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