SynthesisClinical research in cardiology : official journal of the German Cardiac Society2021
Echocardiography versus computed tomography and cardiac magnetic resonance for the detection of left heart thrombosis: a systematic review and meta-analysis.
Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Cardiac Computed Tomography Versus Transesophageal Echocardiography for the Detection of Left Atrial Appendage Thrombus: A Systemic Review and Meta-Analysis.Journal of the American Heart Association · 2021Pooled it
- Calculation of Ejection Fraction Using Cardiac Computed Tomography: Clinical Evolution, Reliability, and Technological Challenges-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- Left Ventricular Thrombosis Secondary to Severe Myocardial Contusion Without Coronary Artery Injury Following Blunt Injury: A Case Report.Journal of clinical medicine · 2026Article
- Left atrial appendage thrombus detection in routine workflow for patients with atrial fibrillation under oral anticoagulation: transoesophageal echocardiography vs. cardiac computed tomography.European heart journal. Imaging methods and practice · 2025Article
- 2025 THRS Expert Consensus of Imaging Assessment in Atrial Fibrillation.Acta Cardiologica Sinica · 2025Article
- Multimodality Cardiac Imaging in Ischemic Stroke: Insights into the Heart-Brain Interaction.Cardiology · 2025Review
- Prediction of spontaneous echocardiographic contrast within the left atrial appendage in cardiac computed tomography of patients with atrial fibrillation.Heart and vessels · 2023Article
- A systematic review and meta-analysis of transthoracic echocardiogram vs. cardiac magnetic resonance imaging for the detection of left ventricular thrombus.European heart journal. Imaging methods and practice · 2023Review
- Where Is the Left Atrial Appendage Wall? Caution during Transesophageal Echocardiography.CASE (Philadelphia, Pa.) · 2023Article
- Left ventricular thrombus in a patient with recurrent ischemic stroke events-The role of echocardiography.Clinical case reports · 2023Article
- Left Atrial Thrombus in Patients With Non-valvular Atrial Fibrillation: A Cross-Sectional Study in China.Frontiers in cardiovascular medicine · 2022Article
- Transesophageal Echocardiography in Ischemic Stroke With Atrial Fibrillation.Journal of the American Heart Association · 2021Article
- Left atrial appendage elimination techniques: stapled excision versus internal suture obliteration.Journal of thoracic disease · 2021Article
- State of the art paper: Cardiac computed tomography of the left atrium in atrial fibrillation.Journal of cardiovascular computed tomographyReview
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate and reproducible diagnostic techniques are essential to detect left-sided cardiac thrombi [either in the left ventricle (LV) or in the left atrial appendage (LAA)] and to guide the onset and duration of antithrombotic treatment while minimizing the risk for thromboembolic and hemorrhagic events.
methodsWe conducted a systematic review and meta-analysis aiming to compare the diagnostic performance of transthoracic echocardiography (TTE) vs. cardiac magnetic resonance (CMR) for the detection of LV thrombi, and transesophageal echocardiography (TEE) vs. computed tomography (CT) for the detection of LAA thrombi.
resultsSix studies were included in the first meta-analysis (TTE vs. CMR for LV thrombosis). Pooled sensitivity and specificity values were 62% [95% confidence interval (CI), 37-81%] and 97% (95% CI, 94-99%). The shape of the hierarchical summary receiver operating characteristic (HSROC) curve and the area under the curve (AUC) of 0.96 suggested a high accuracy. Ten studies were included in the second meta-analysis (CT versus TEE for LAA thrombosis). The pooled values of sensitivity and specificity were 97% (95% CI, 77-100%) and 94% (95% CI, 87-98%). The pooled diagnostic odds ratio (DOR) was 500 (95% CI, 52-4810), and the pooled likelihood ratios (LR + and LR-) were 17% (95% CI, 7-40%) and 3% (95% CI, 0-28%). The shape of the HSROC curve and 0.99 AUC suggested a high accuracy of CT vs. TEE.
conclusionsTTE is a fair alternative to DE-CMR for the identification of LV thrombi, while CT has a good accuracy compared to TEE for the detection of LAA thrombosis. PROSPERO REGISTRATION: CRD42020185842.
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