Evidence map›Paper›PMID 32920523›Full record

ReviewCurrent opinion in chemical biology2020

Recent progress in chemical synthesis of bacterial surface glycans.

Riyao Li, Hai Yu, Xi Chen

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Defined Glycan Ligands for Detecting Rare l-Sugar-Binding Proteins.Journal of the American Chemical Society · 2025
    Article
  7. Synthesis of Fluorinated Glycotope Mimetics Derived fromInternational journal of molecular sciences · 2025
    Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Riyao LiDepartment of Chemistry, University of California Davis, Davis, CA, USA.
Hai YuDepartment of Chemistry, University of California Davis, Davis, CA, USA.
Xi ChenDepartment of Chemistry, University of California Davis, Davis, CA, USA. Electronic address: xiichen@ucdavis.edu.
University of California, Davis · US

Funding

Chemoenzymatic synthesis of bacterial polysaccharidesU01GM125288 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KIESSLING, LAURA L, LI, LEI · 2017 to 2020
$3.1M
Facile chemoenzymatic synthesis and purification of glycolipidsU01GM120419 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI · 2016 to 2019
$2.8M
Supplement: Exploring the biology of O-acetyl sialic acids using stable synthetic mimicsR01AI130684 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN, XI, VARKI, AJIT P · 2017 to 2020
$2.3M
NIAID NIH HHS R01 AI130684NIGMS NIH HHS U01 GM120419NIGMS NIH HHS U01 GM125288
6 · The paper itself

Abstract

With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan-protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.

Indexed as

BacteriaChemistry Techniques, SyntheticPolysaccharidesPolysaccharidesBacterial glycanCarbohydrateGlycoconjugate vaccineGlycosyltransferaseSynthesis

Identifiers

PMID32920523
PMCPMC7880230
OpenAlexW3086477288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.