Evidence map›Paper›PMID 32920522›Full record

ArticleCell calcium2020

Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats.

Tatiana Romero-García, Huguet V Landa-Galvan, Natalia Pavón, Martha Mercado-Morales, Héctor H Valdivia, Angélica Rueda

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. CaPflugers Archiv : European journal of physiology · 2022
    Review
  9. Tale of two kinases: Protein kinase A and CaWorld journal of diabetes · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tatiana Romero-GarcíaDepartment of Biochemistry, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Mexico City, 07300 Mexico.
Huguet V Landa-GalvanDepartment of Biochemistry, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Mexico City, 07300 Mexico.
Natalia PavónDepartment of Pharmacology, Instituto Nacional de Cardiología "Ignacio Chavez", Mexico City, Mexico.
Martha Mercado-MoralesDepartment of Biochemistry, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Mexico City, 07300 Mexico.
Héctor H ValdiviaDepartment of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Angélica RuedaDepartment of Biochemistry, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Mexico City, 07300 Mexico. Electronic address: arueda@cinvestav.mx.
Instituto Politécnico Nacional · MXCenter for Research and Advanced Studies of the National Polytechnic Institute · MXInstituto Nacional de Cardiología · MXUniversity of Wisconsin–Madison · US

Funding

Ryanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0M
Natural Agonists of Ryanodine Receptors: Structure-function Relationship and Antiarrhythmic PropertiesR01HL134344 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2017 to 2020
$1.9M
NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL134344
6 · The paper itself

Abstract

Autonomous Ca

Indexed as

DiastoleAnimalsCalciumCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2IsoproterenolMaleMetabolic SyndromeMyocytes, CardiacPeptidesPhospholambanPhosphorylationRats, WistarReceptors, Adrenergic, betaRyanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesautocamptide-2-related inhibitory peptide IICalciumCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2IsoproterenolPeptidesPhospholambanReceptors, Adrenergic, betaRyanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesCa(2+)/calmodulin-dependent protein kinase type IICardiac ryanodine receptor phosphorylationDiastolic Ca(2+)leakHigh sucrose dietMetabolic syndromeβ-adrenergic stimulation

Identifiers

PMID32920522
PMCPMC7530131
OpenAlexW3048673940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.