ArticleEBioMedicine2020
Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous thromboembolism - results from clinical observation studies.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome: A systemic review and meta-analysis.PloS one · 2024Pooled it
- Risk and mediation analysis of early β-blocker use on survival outcomes in sepsis patients and new-onset atrial fibrillation: an analysis of the MIMIC-IV database.Journal of thoracic disease · 2026Article
- Integrating platelet-rich plasma therapy into nursing practice: a review of biological mechanisms and clinical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Low-Molecular-Weight Fucoidan Inhibits Thromboinflammation and Ameliorates Deep Vein Thrombosis via Targeting S100A8/A9.Marine drugs · 2025Article
- Clinical characteristics analysis of stroke patients with lower extremity deep venous thrombosis.Frontiers in neurology · 2025Article
- Increased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease.TH open : companion journal to thrombosis and haemostasis · 2024Article
- Subphenotypes of platelet count trajectories in sepsis from multi-center ICU data.Scientific reports · 2024Observational
- Nomogram for hospital-acquired venous thromboembolism among patients with cardiovascular diseases.Thrombosis journal · 2024Article
- Dynamic observation of circRNA and mRNA profiles in a rat model of deep vein thrombosis.Experimental and therapeutic medicine · 2023Article
- Predictive factors on postoperative venous thromboembolism after minimally invasive colorectal cancer surgery: a retrospective observational study.BMC surgery · 2023Observational
- Platelet indices and blood pressure: a multivariable mendelian randomization study.Thrombosis journal · 2023Article
- Analysis of risk factors for deep vein thrombosis after spinal infection surgery and construction of a nomogram preoperative prediction model.Frontiers in cellular and infection microbiology · 2023Article
- Article
- The interaction of vortical flows with red cells in venous valve mimics.Biomicrofluidics · 2022Article
- Association of longitudinal platelet count trajectory with ICU mortality: A multi-cohort study.Frontiers in immunology · 2022Article
- Humic Acids Inhibit Platelet Activation to Reduce Venous Thromboembolism in Mice.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Thrombo-Inflammation: A Focus on NTPDase1/CD39.Cells · 2021Review
- Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease.Frontiers in cardiovascular medicine · 2021Review
- Analysis of Risk Factors of Postoperative Lower Extremity Deep Venous Thrombosis in Patients With Cervical Cancer.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
- Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathogenesis of arterial and venous thrombosis is in large part interlaced. How much platelet phenotype relates to acute venous thromboembolism (VTE) independent of the underlying cardiovascular profile is presently poorly investigated.
methodsPlatelet count and mean platelet volume (MPV), platelet aggregation in whole blood and platelet rich plasma (PRP), platelet-dependent thrombin generation (TG) and platelet surface activation markers were measured under standardized conditions. Machine learning was applied to identify the most relevant characteristics associated with VTE from a large array (N = 58) of clinical and platelet-related variables.
findingsVTE cases (N = 159) presented with lower platelet count and MPV vs controls (N = 140). Whole blood aggregation showed shorter collagen/Epinephrine closure times in cases, particularly within acetylsalicylic acid (ASA) users. Within ASA users, higher PRP aggregation after adenosine diphosphate (ADP), epinephrine, collagen and arachidonic acid was observed in cases vs controls. Within non-ASA and/or subjects on anticoagulants, cases presented with lower aggregation after ADP and collagen vs controls. Lower platelet-dependent TG, higher CD63 on resting and lower PAC-1 expression after collagen/ADP in-vitro stimulated platelets further characterized VTE cases vs controls, independent of therapy. Lasso regression analysis identified 26 variables associated with VTE of which 69% were platelet-related.
interpretationComprehensive phenotyping of platelet function identified a large proportion of low responders to ASA in VTE cases. Lower platelet-dependent TG and lower platelet reactivity after ex-vivo stimulation characterized the "platelet exhausted syndrome" in cases. Finally, from a large array of covariates including clinical risk factors, platelet biomarkers comprised 69% of all selected variables differentiating VTE cases vs controls.
fundingGerman Federal Ministry of Education and Research, CTH-Mainz and Bayer AG.
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