Evidence map›Paper›PMID 32920100›Full record

ArticleAnnals of epidemiology2021

Prepregnancy handling of antineoplastic drugs and risk of miscarriage in female nurses.

Feiby L Nassan, Jorge E Chavarro, Candice Y Johnson, James M Boiano, Carissa M Rocheleau, Janet W Rich-Edwards, Christina C Lawson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Safe handling of hazardous drugs.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2023
    Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Feiby L NassanDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA. Electronic address: fen769@mail.harvard.edu.
Jorge E ChavarroDepartment of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA.
Candice Y JohnsonNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH.
James M BoianoNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH.
Carissa M RocheleauNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH.
Janet W Rich-EdwardsDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA; Connors Center for Women's Health and Gender Biology and Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Christina C LawsonNational Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH.
Centers for Disease Control and Prevention · USHarvard University · USBrigham and Women's Hospital · USNational Institute for Occupational Safety and Health · US

Funding

Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Nurses Health Study 3: A multiple exposure environmental epidemiology cohort of young adultsR24ES028521 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, LADEN, FRANCINE · 2018 to 2022
$2.1M
NHLBI NIH HHS U01 HL145386NIEHS NIH HHS R24 ES028521NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

purposeTo examine the association betweenantineoplastic drug (AD) handling and risk of miscarriage.

methodsNurses' Health Study-3 participants self-reported AD administration and engineering controls (ECs) and personal protective equipment (PPE) use at baseline. We estimated the hazard ratio (HR) of miscarriage in relation to baseline AD handling using multivariable Cox proportional regression.

resultsOverall, 2440 nurses reported 3327 pregnancies, with 550 (17%) ended in miscarriages. Twelve percent of nurses self-reported currently handling AD and 28% previously handling AD. Compared with nurses who never handled AD, nurses who handled AD at baseline had an adjusted HR of miscarriage of 1.26 (95% confidence interval [CI], 0.97-1.64). This association was stronger after 12-weeks gestation (HR=2.39 [95% CI, 1.13-5.07]). Nurses who did not always use gloves had HR of 1.51 (95% CI, 0.91-2.51) compared with 1.19 (95% CI, 0.89-1.60) for those always using gloves; nurses who did not always use gowns had HR of 1.32 (95% CI, 0.95-1.83) compared with 1.19 (95% CI, 0.81-1.75) for nurses always using gowns.

conclusionsWe observed a suggestive association between AD handling and miscarriage, particularly among nurses who did not consistently use PPE and EC with stronger associations for second trimester losses.

Indexed as

Abortion, SpontaneousAntineoplastic AgentsNursesOccupational ExposureAdultFemaleGloves, ProtectiveHumansPregnancyProtective ClothingRiskAntineoplastic AgentsAntineoplastic drugsExposure controlsMiscarriageNursesNurses' Health StudyOccupational exposure

Identifiers

PMID32920100
PMCPMC7736108
OpenAlexW3085333850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.