Evidence map›Paper›PMID 32920046›Full record

ArticleNeuroscience letters2020

Improved visual discrimination learning in mice with partial 5-HT2B gene deletion.

Anna K Radke, Patrick T Piantadosi, George R Uhl, F Scott Hall, Andrew Holmes

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anna K RadkeDepartment of Psychology, Miami University, Oxford, OH, USA. Electronic address: aradke@miamioh.edu.
Patrick T PiantadosiLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
George R UhlNeurology, Neuroscience, Molecular Genetics & Microbiology, NMVAHCS and University of New Mexico, Albuquerque, NM, USA; National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
F Scott HallDepartment of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH, USA; National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Andrew HolmesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USMiami University · US

Funding

Mouse models of the early life origins of stress disordeZ01AA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2004 to 2008
$1.9M
GENETIC APPROACHES TO CHARACTERIZING DRUG RESPONSES AND VULNERABILITIES: MICEZ01DA000165 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI UHL, GEORGE RICHARD · 1995 to 2008
$1.5M
Intramural NIH HHS Z01 AA000411Intramural NIH HHS Z01 DA000165
6 · The paper itself

Abstract

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been linked to multiple aspects of cognition. For example, in rodents, discrimination and reversal learning are altered by experimentally induced changes in brain serotonin levels, and reduced expression of the 5-HT

Indexed as

Gene DeletionReversal LearningAnimalsCognitionConditioning, OperantDiscrimination LearningDiscrimination, PsychologicalMaleMiceReceptor, Serotonin, 5-HT2BVisual PerceptionReceptor, Serotonin, 5-HT2BBehavioral flexibilityDiscriminationFearLearningSerotoninTouchscreen

Identifiers

PMID32920046
PMCPMC7584752
OpenAlexW3085081826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.