ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2020
Identification of Need for Ultrasound Enhancing Agent Study (the IN-USE Study).
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Development of a screening checklist to identify individuals with suspected allergy to polyethylene glycol.Echo research and practice · 2025Article
- Standardizing Safety Practices for Contrast-Enhanced Ultrasound in Radiology.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- Use of Ultrasound Contrast Agents in Stress Echocardiography: Three for the Price of One.CASE (Philadelphia, Pa.) · 2025Article
- Contemporary Safety of Ultrasound Enhancing Agents in a Nationwide Analysis.Journal of the American Heart Association · 2025Article
- External validation of artificial intelligence for detection of heart failure with preserved ejection fraction.Nature communications · 2025Article
- Multi-societal expert consensus statement on the safe administration of ultrasound contrast agents.Echo research and practice · 2025Review
- A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for Definity.PloS one · 2025Article
- Development and internal validation of an age less-dependent frailty score in the cardiovascular health study.Frontiers in medicine · 2025Article
- Validation of administrative claims to identify ultrasound enhancing agent use.Echo research and practice · 2024Article
- External Validation of the Identification of Need for Ultrasound Enhancing Agent Study (the IN-USE Study).Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022Article
- Determinants of image quality in transthoracic echocardiography: A retrospective cohort study.JRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundUltrasound enhancing agents (UEAs) are routinely used to improve transthoracic echocardiographic (TTE) image quality, yet anticipation of UEA need is a barrier to their use.
methodsStructured report data from 171,509 consecutive TTE studies in 97,515 patients who underwent TTE imaging from January 26, 2000, to September 20, 2018, were analyzed. Trends in UEA use and suboptimal image quality were examined. Among outpatients (92,291 TTE examinations, n = 56,479), the data set was randomly split into a 75% derivation sample and a 25% validation sample. Logistic regression was used to model the composite of either UEA receipt or suboptimal image quality (two or more nonvisualized segments) using only variables available at the start of the TTE examination. Model performance was tested in the validation sample.
resultsA total of 4,444 TTE examinations (2.6%) in 3,827 patients (3.9%) involved UEAs, and 28,468 TTE examinations (16.6%) in 21,994 patients (22.5%) were suboptimal. UEA use increased over the observation period. Among TTE studies with suboptimal image quality, UEA use was lower in women (P < .0001). Among outpatients referred for TTE imaging, older age, greater weight, and higher heart rate best predicted UEA use or suboptimal image quality. Model performance in the validation sample was excellent (C statistic = 0.74 [95% CI, 0.73-0.75]; calibration slope = 1.11 [95% CI, 1.06-1.15]).
conclusionsIn this large, single-center, retrospective study, UEA use remained substantially below rates of suboptimal image quality, despite increases over time. Among outpatients, a simple prediction rule using three routinely collected variables available before TTE image acquisition predicted potential benefit from UEAs with high accuracy. If confirmed in other cohorts, this rule may be used to identify patients who may benefit from intravenous placement for UEA administration before TTE image acquisition, thus potentially improving work-flow efficiency.
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