ArticleBiological psychiatry2021
Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Cross-ancestry and cross-disorder transferability of polygenic risk scores for obsessive-compulsive disorder.Translational psychiatry · 2026Article
- Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study.Npj mental health research · 2026Article
- Angiographic Burden of Coronary Atherosclerosis Partially Mediates the Association Between ASCVD Risk Factors and Outcomes.Circulation. Genomic and precision medicine · 2026Article
- Limited overlap between genetic effects on disease susceptibility and disease survival.Nature genetics · 2025Article
- Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.Molecular psychiatry · 2025Article
- Article
- Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk.Genome medicine · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations.medRxiv : the preprint server for health sciences · 2024Article
- A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations.Nature. Mental health · 2024Article
- Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data.Molecular psychiatry · 2024Article
- Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.Psychological medicine · 2024Article
- Optimising the use of electronic medical records for large scale research in psychiatry.Translational psychiatry · 2024Review
- Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.Genome biology · 2024Article
- Multi-polygenic scores in psychiatry: From disorder specific to transdiagnostic perspectives.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes.Neuroscience and biobehavioral reviews · 2023Review
- The collaborative study on the genetics of alcoholism: Genetics.Genes, brain, and behavior · 2023Review
- Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.Nature neuroscience · 2023Article
- Evaluation of the Performance of the RECODe Equation with the Addition of Polygenic Risk Scores for Adverse Cardiovascular Outcomes in Individuals with Type II Diabetes.medRxiv : the preprint server for health sciences · 2023Article
- The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders.Genes · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrediction of disease risk is a key component of precision medicine. Common traits such as psychiatric disorders have a complex polygenic architecture, making the identification of a single risk predictor difficult. Polygenic risk scores (PRSs) denoting the sum of an individual's genetic liability for a disorder are a promising biomarker for psychiatric disorders, but they require evaluation in a clinical setting.
methodsWe developed PRSs for 6 psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder, cross disorder, attention-deficit/hyperactivity disorder, and anorexia nervosa) and 17 nonpsychiatric traits in more than 10,000 individuals from the Penn Medicine Biobank with accompanying electronic health records. We performed phenome-wide association analyses to test their association across disease categories.
resultsFour of the 6 psychiatric PRSs were associated with their primary phenotypes (odds ratios from 1.2 to 1.6). Cross-trait associations were identified both within the psychiatric domain and across trait domains. PRSs for coronary artery disease and years of education were significantly associated with psychiatric disorders, largely driven by an association with tobacco use disorder.
conclusionsWe demonstrated that the genetic architecture of electronic health record-derived psychiatric diagnoses is similar to ascertained research cohorts from large consortia. Psychiatric PRSs are moderately associated with psychiatric diagnoses but are not yet clinically predictive in naïve patients. Cross-trait associations for these PRSs suggest a broader effect of genetic liability beyond traditional diagnostic boundaries. As identification of genetic markers increases, including PRSs alongside other clinical risk factors may enhance prediction of psychiatric disorders and associated conditions in clinical registries.
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