ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Methylphenidate boosts choices of mental labor over leisure depending on striatal dopamine synthesis capacity.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Methylphenidate undermines or enhances divergent creativity depending on baseline dopamine synthesis capacity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Effects of repeated low-dose LSD on neuropsychological functioning in adults with ADHD: a randomized placebo-controlled study.Psychopharmacology · 2026Article
- Is poor control over thoughts and emotions related to a higher tendency to delay tasks? The link between procrastination, emotional dysregulation and attentional control.British journal of psychology (London, England : 1953) · 2025Article
- Striatal dopamine can enhance both fast working memory, and slow reinforcement learning, while reducing implicit effort cost sensitivity.Nature communications · 2025Article
- Efficacy of Methylphenidate in Patients With Brain Disease: A Systematic Review and Meta-Analysis.Brain & NeuroRehabilitation · 2025Article
- Shielding working memory from distraction is more effortful than flexible updating.Scientific reports · 2025Article
- Mechanisms of Post-Stroke Fatigue: A Follow-Up From the Third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Review
- Article
- Behavioral, Neurochemical and Developmental Effects of Chronic Oral Methylphenidate: A Review.Journal of personalized medicine · 2023Review
- Dopamine increases risky choice while D2 blockade shortens decision time.Experimental brain research · 2022Article
- Preferences for seeking effort or reward information bias the willingness to work.Scientific reports · 2022Article
- Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning.Nature communications · 2022Article
- Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder.BMC psychiatry · 2022Article
- Domain-general cognitive motivation: Evidence from economic decision-making - Final Registered Report.Cognitive research: principles and implications · 2022Article
- Effects of average reward rate on vigor as a function of individual variation in striatal dopamine.Psychopharmacology · 2022Article
- Influences of dopaminergic system dysfunction on late-life depression.Molecular psychiatry · 2022Review
- Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- A mosaic of cost-benefit control over cortico-striatal circuitry.Trends in cognitive sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The cognitive enhancing effects of methylphenidate are well established, but the mechanisms remain unclear. We recently demonstrated that methylphenidate boosts cognitive motivation by enhancing the weight on the benefits of a cognitive task in a manner that depended on striatal dopamine. Here, we considered the complementary hypothesis that methylphenidate might also act by changing the weight on the opportunity cost of a cognitive task, that is, the cost of foregoing alternative opportunity. To this end, 50 healthy participants (25 women) completed a novel cognitive effort-discounting task that required choices between task and leisure. They were tested on methylphenidate, placebo, as well as the selective D2-receptor agent sulpiride, the latter to strengthen inference about dopamine receptor selectivity of methylphenidate's effects. Furthermore, they also underwent an [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.