ArticlePediatric research2021
Inter-device reproducibility of transcutaneous bilirubin meters.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Universal screening for hyperbilirubinemia in term healthy newborns at discharge: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Bilirubin rate of rise during routine 6-h transcutaneous bilirubin surveillance.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Reconsidering transcutaneous bilirubinometry for management of neonatal hyperbilirubinemia: is it time for change?Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Wearable Multispectral Sensor for Newborn Jaundice Monitoring.Sensors (Basel, Switzerland) · 2025Article
- Effect of skin color and other skin properties on the delivered light dose in phototherapy for neonatal hyperbilirubinemia.Biophotonics discovery · 2025Article
- Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation.Pediatric research · 2025Article
- Assessing accuracy of BiliPredics algorithm in predicting individual bilirubin progression in neonates-results from a prospective multi-center study.Frontiers in digital health · 2025Article
- Design and characterization of color printed polyurethane films as biomedical phantom layers.Biomedical optics express · 2023Article
- Quantification of cephalocaudal progression of jaundice in preterm infants.Pediatric research · 2023Article
- Transcutaneous bilirubin measurements: useful, but also reproducible?Pediatric research · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscutaneous bilirubinometry is a widely used screening method for neonatal hyperbilirubinemia. Deviation of the transcutaneous bilirubin concentration (TcB) from the total serum bilirubin concentration (TSB) is often ascribed to biological variation between patients, but variations between TcB meters may also have a role. This study aims to provide a systematic evaluation of the inter-device reproducibility of TcB meters. MATERIALS AND
methodsThirteen commercially available TcB meters (JM-105 and JM-103) were evaluated in vitro on phantoms that optically mimic neonatal skin. The mimicked TcB was varied within the clinical range (0.5-181.3 μmol/L).
resultsAbsolute differences between TcB meter outcomes increased with the measured TcB, from a difference of 5.0 μmol/L (TcB = 0.5 μmol/L phantom) up to 65.0 μmol/L (TcB = 181.3 μmol/L phantom).
conclusionThe inter-device reproducibility of the examined TcB meters is substantial and exceeds the specified accuracy of the device (±25.5 μmol/L), as well as the clinically used TcB safety margins (>50 µmol/L below phototherapy threshold). Healthcare providers should be well aware of this additional uncertainty in the TcB determination, especially when multiple TcB meters are employed in the same clinic. We strongly advise using a single TcB meter per patient to evaluate the TcB over time. IMPACT: Key message: The inter-device reproducibility of TcB meters is substantial and exceeds the clinically used TcB safety margins. What this study adds to existing literature: The inter-device reproducibility of transcutaneous bilirubin (TcB) meters has not been reported in the existing literature. This in vitro study systematically evaluates this inter-device reproducibility. IMPACT: This study aids in a better interpretation of the measured TcB value from a patient and is of particular importance during patient monitoring when using multiple TcB meters within the same clinical department. We strongly advise using a single TcB meter per patient to evaluate the TcB over time.
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