ArticleDrug and alcohol dependence2020
Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07461350 (Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)
Who cites it
23 citing papers in PubMed, 23 citations in OpenAlex.
- Associations Between Sustained Methamphetamine/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV.Journal of the American Heart Association · 2026Article
- Article
- Unmet Subsistence and Mental Health Needs in Women Experiencing Homelessness: Rethinking Care Models for Improved Outcomes.Journal of general internal medicine · 2025Article
- Distinct cardiac troponin alterations in patients with cocaine and alcohol use disorders during abstinence for cardiovascular risk assessment.Scientific reports · 2025Observational
- Article
- Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Distinct patterns of cigarette smoking intensity and other substance use among women who experience housing instability.Addictive behaviors · 2024Article
- Evaluation of methamphetamine assist packs: As-needed antipsychotics for self-management of methamphetamine-associated psychiatric toxicity.The International journal on drug policy · 2024Article
- Brief Report: The Role of Substance Use in Structural Heart Disease Among Women Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2024Article
- Cardiovascular Risks of Simultaneous Use of Alcohol and Cocaine-A Systematic Review.Journal of clinical medicine · 2024Review
- Cocaine Use is Associated With Increased LVMI in Unstably Housed Women With Polysubstance Use.Substance abuse · 2023Article
- Housing Instability Associated with Return to Stimulant Use among Previously Abstaining Women.International journal of environmental research and public health · 2023Article
- Multiple substance use and blood pressure in women experiencing homelessness.Addictive behaviors reports · 2023Article
- Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2023Article
- Racial, ethnic, and age disparities in the association of mental health symptoms and polysubstance use among persons in HIV care.PloS one · 2023Article
- Impact of multiple substance use on circulating ST2, a biomarker of adverse cardiac remodelling, in women.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2022Article
- A Chronic Condition Disguised as an Acute Event: the Case for Re-thinking Stimulant Overdose Death.Journal of general internal medicine · 2022Article
- Review
- "It's called overamping": experiences of overdose among people who use methamphetamine.Harm reduction journal · 2022Article
- Homeless women's perspectives on smoking and smoking cessation programs: A qualitative study.The International journal on drug policy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe use of controlled substances like cocaine increases the risk of cardiovascular disease (CVD) and myocardial infarction (MI). However, outside of alcohol and tobacco, substance use is not included in CVD risk assessment tools. We identified the effects of using multiple substances (nicotine/cotinine, cannabis, alcohol, cocaine, methamphetamine, heroin and other opioids) on cardiac injury measured by high-sensitivity troponin (hsTnI) in homeless and unstably housed women.
methodsWe recruited 245 homeless and unstably housed women from shelters, free meal programs and street encampments. Participants completed six monthly study visits. Adjusting for traditional CVD risk factors, we examined longitudinal associations between substance use and hsTnI.
resultsMedian participant age was 53 years and 74 % were ethnic minority women. At baseline, 76 % of participants had hypertension, 31 % were HIV-positive, 8% had a history of a prior MI and 12 % of prior stroke. The most commonly used substances were cotinine/nicotine (80 %), cannabis (68 %) and cocaine (66 %). HsTnI exceeding the 99th percentile (14.7 ng/L) - a level high enough to signal possible MI - was observed in 14 participants during >1 study visit (6%). In adjusted analysis, cocaethylene and fentanyl were significantly associated with higher hsTnI levels.
conclusionsFentanyl use and the co-use of cocaine and alcohol are associated with myocardial injury, suggesting that the use of these substances may act as long-term cardiac insults. Whether risk counseling on these specific substances and/or including their use in CVD risk stratification would improve CVD outcomes in populations where substance use is high merits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.