Evidence map›Paper›PMID 32918985›Full record

Observational studyResuscitation2020

Predicting intensive care unit admission and death for COVID-19 patients in the emergency department using early warning scores.

Marcello Covino, Claudio Sandroni, Michele Santoro, Luca Sabia, Benedetta Simeoni, Maria Grazia Bocci, Veronica Ojetti, Marcello Candelli, Massimo Antonelli, Antonio Gasbarrini and 1 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Resuscitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Assessing Risk of Early ICU Admission or Death at Emergency Department Triage: Clinical Judgment Versus Early Warning Scores.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026
    Observational
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  6. [Performance of prognostic scores during the first and second waves of COVID-19 pneumonia]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2026
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  8. Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Marcello CovinoEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Claudio SandroniDepartment of Intensive Care, Emergency Medicine and Anaesthesiology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy; Institute of Anaesthesiology and Intensive Care Medicine, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: claudio.sandroni@policlinicogemelli.it.
Michele SantoroEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Luca SabiaEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Benedetta SimeoniEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Maria Grazia BocciDepartment of Intensive Care, Emergency Medicine and Anaesthesiology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.
Veronica OjettiEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy; Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Marcello CandelliEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Massimo AntonelliDepartment of Intensive Care, Emergency Medicine and Anaesthesiology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy; Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Antonio GasbarriniDepartment of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy; Institute of Internal Medicine and Gastroenterology, Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco FranceschiEmergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy; Institute of Emergency Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo identify the most accurate early warning score (EWS) for predicting an adverse outcome in COVID-19 patients admitted to the emergency department (ED).

methodsIn adult consecutive patients admitted (March 1-April 15, 2020) to the ED of a major referral centre for COVID-19, we retrospectively calculated NEWS, NEWS2, NEWS-C, MEWS, qSOFA, and REMS from physiological variables measured on arrival. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV), and the area under the receiver operating characteristic (AUROC) curve of each EWS for predicting admission to the intensive care unit (ICU) and death at 48 h and 7 days were calculated.

resultsWe included 334 patients (119 [35.6%] females, median age 66 [54-78] years). At 7 days, the rates of ICU admission and death were 56/334 (17%) and 26/334 (7.8%), respectively. NEWS was the most accurate predictor of ICU admission within 7 days (AUROC 0.783 [95% CI, 0.735-0.826]; sensitivity 71.4 [57.8-82.7]%; NPV 93.1 [89.8-95.3]%), while REMS was the most accurate predictor of death within 7 days (AUROC 0.823 [0.778-0.863]; sensitivity 96.1 [80.4-99.9]%; NPV 99.4[96.2-99.9]%). Similar results were observed for ICU admission and death at 48 h. NEWS and REMS were as accurate as the triage system used in our ED. MEWS and qSOFA had the lowest overall accuracy for both outcomes.

conclusionIn our single-centre cohort of COVID-19 patients, NEWS and REMS measured on ED arrival were the most sensitive predictors of 7-day ICU admission or death. EWS could be useful to identify patients with low risk of clinical deterioration.

Indexed as

BetacoronavirusAgedCoronavirus InfectionsCOVID-19Early Warning ScoreFemaleHospital MortalityHumansIntensive Care UnitsItalyMaleMiddle AgedPandemicsPatient AdmissionPneumonia, ViralRetrospective StudiesCOVID-19Early warning scoresMEWSNEWSNEWS2qSOFAREMS

Identifiers

PMID32918985
PMCPMC7480278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.