Evidence map›Paper›PMID 32918907›Full record

Trial reportArchives of physical medicine and rehabilitation2021

Forced and Voluntary Aerobic Cycling Interventions Improve Walking Capacity in Individuals With Chronic Stroke.

Susan M Linder, Sara Davidson, Anson Rosenfeldt, John Lee, Mandy Miller Koop, Francois Bethoux, Jay L Alberts

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Susan M LinderDepartment of Physical Medicine and Rehabilitation, Cleveland Clinic, Cleveland, OH; Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH; Concussion Center, Cleveland Clinic, Cleveland, OH. Electronic address: linders@ccf.org.
Sara DavidsonConcussion Center, Cleveland Clinic, Cleveland, OH.
Anson RosenfeldtDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH.
John LeeDepartment of Physical Medicine and Rehabilitation, Cleveland Clinic, Cleveland, OH.
Mandy Miller KoopDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH.
Francois BethouxDepartment of Physical Medicine and Rehabilitation, Cleveland Clinic, Cleveland, OH.
Jay L AlbertsDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH; Concussion Center, Cleveland Clinic, Cleveland, OH; Center for Neurologic Restoration, Cleveland Clinic, Cleveland, OH.

Funding

Heart-Brain Retraining: Forced Aerobic exercise for Stroke RehabilitationR03HD073566 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L., LINDER, SUSAN MARIE · 2012 to 2013
$145k
NICHD NIH HHS R03 HD073566
6 · The paper itself

Abstract

objectivesTo determine the efficacy of high-intensity cycling to improve walking capacity in individuals with chronic stroke, identify variables that predict improvement in walking capacity, and quantify the relationship between the 6-minute walk test (6MWT) and cardiopulmonary exercise (CPX) test variables.

designSecondary analysis of data from 2 randomized controlled trials.

settingResearch laboratory.

participantsIndividuals with chronic stroke (N=43).

interventionsParticipants were randomized to 1 of the following time-matched interventions, occurring 3 times per week for 8 weeks: (1) forced aerobic exercise and upper extremity repetitive task practice (FE+RTP [n=16]), (2) voluntary aerobic exercise and upper extremity repetitive task practice (VE+RTP [n=14]), or (3) a non-aerobic control group (n=13).

main outcome measureChange in walking capacity as measured by the 6MWT from baseline to the end of treatment (EOT).

resultsSignificant increases were observed in distance traveled during the 6MWT at the EOT compared with baseline in the FE+RTP (P<.001) and VE+RTP (P<.001) groups, but not in the control group (P=.21). Among aerobic exercise participants, a multivariate regression analysis revealed that cycling cadence, power output, and baseline 6MWT distance were significant predictors of change in walking capacity.

conclusionsAn 8-week aerobic cycling intervention prescribed at 60% to 80% of heart rate reserve and moderate to high cadence and resistance led to significant improvements in walking capacity in our cohort of individuals with chronic stroke. Individuals with low baseline walking capacity levels may benefit most from aerobic cycling to improve over ground locomotion. Although the 6MWT did not elicit a cardiorespiratory response comparable to the maximal exertion CPX test, the 6MWT can be considered a valid and clinically relevant submaximal test of cardiorespiratory function in individuals with chronic stroke.

Indexed as

AdultAgedBicyclingCardiorespiratory FitnessExercise TherapyExercise ToleranceFemaleHumansMaleMiddle AgedOxygen ConsumptionStroke RehabilitationUpper ExtremityWalkingExerciseHemiplegiaStroke rehabilitationWalking and bicyclingWalking speed

Identifiers

PMID32918907
PMCPMC7796862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.