ArticleAngewandte Chemie (International ed. in English)2020
Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2025Review
- Directed Self-Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultrasound-Induced Nitric Oxide-Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Stable and Highly Steerable Magnetic Nanorobots Demonstrate Therapeutical Functionality in Crowded Biological Media.ACS nano · 2025Article
- Anisotropy, topography and non-newtonian properties of cellular interiors probed by helical magnetic nanobots.Journal of micro-bio robotics · 2025Article
- Cell Membrane Sialome: Sialic Acids as Therapeutic Targets and Regulators of Drug Resistance in Human Cancer Management.Cancers · 2023Review
- Analysing the motion of scallop-like swimmers in a noisy environment.The European physical journal. Special topics · 2023Article
- How safe are magnetic nanomotors: From cells to animals.Biomaterials advances · 2022Article
- Fluid flow induced by helical microswimmers in bulk and near walls.Physical review research · 2022Article
- Mobile Nanobots for Prevention of Root Canal Treatment Failure.Advanced healthcare materials · 2022Article
- Explaining chemical clues of metal organic framework-nanozyme nano-/micro-motors in targeted treatment of cancers: benchmarks and challenges.Journal of nanobiotechnology · 2022Review
- High shear rate propulsion of acoustic microrobots in complex biological fluids.Science advances · 2022Article
- Passive and Active Microrheology for Biomedical Systems.Frontiers in bioengineering and biotechnology · 2022Review
- 3D magnetically controlled spatiotemporal probing and actuation of collagen networks from a single cell perspective.Lab on a chip · 2021Article
- Review
- Mapping Viscoelastic Properties Using Helical Magnetic Nanopropellers.Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology · 2021Article
- Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*.Angewandte Chemie (International ed. in English) · 2020Article
- Recent Advances in Microswimmers for Biomedical Applications.Micromachines · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer progression. In this paper, we use an active untethered nanomechanical tool, realized as magnetically driven nanomotors, to locally probe a 3D tissue culture environment. We observed that nanomotors preferentially adhere to the cancer-proximal ECM and magnitude of the adhesive force increased with cell lines of higher metastatic ability. We experimentally confirmed that sialic acid linkage specific to cancer-secreted ECM makes it differently charged, which causes this adhesion. In an assay consisting of both cancerous and non-cancerous epithelia, that mimics the in vivo histopathological milieu of a malignant breast tumor, we find that nanomotors preferentially decorate the region around the cancer cells.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.