ReviewJournal of diabetes investigation2021
Current concepts in the management of diabetic polyneuropathy.
Review in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Artificial intelligence for detection, prediction, and severity classification of diabetic peripheral neuropathy: a systematic review.BMC medical informatics and decision making · 2026Pooled it
- The Landscape of Products for Diabetic Peripheral Neuropathy: A Scientific and Patent Systematic Review.Recent patents on biotechnology · 2025Pooled it
- Risk factors for falls in older adults with diabetes mellitus: systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Alpha-lipoic acid for diabetic peripheral neuropathy.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of low-power laser therapy and low-frequency ultrasound in reducing pain in patients with diabetic polyneuropathy: A randomized controlled trial.Lasers in medical science · 2025Trial
- [Value of shear wave elastography in the early diagnosis of DPN in patients with type 2 diabetes mellitus].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Targeting Oxidative Stress and Mitochondrial Dysfunction in Diabetic Neuropathy: Mechanisms and Therapeutic Opportunities.Antioxidants (Basel, Switzerland) · 2026Review
- Multifactorial Inspiratory Muscle Training in Patients With Diabetic Polyneuropathy: A Qualitative Study.Journal of diabetes research · 2026Article
- The success-failure inversion in modern medicine.Frontiers in public health · 2026Article
- Diagnostic value of shear wave elastography for diabetic peripheral neuropathy: comparison between junior radiologists and senior radiologists.BMC medical imaging · 2025Article
- Quantitative sensory testing and skin biopsy for neuropathy assessment in Portuguese patients with type 1 diabetes: an exploratory study.Endocrine · 2025Article
- Feasibility of Viscosity Imaging and Shear Wave Elastography for Diagnosing Diabetic Peripheral Neuropathy.Korean journal of radiology · 2025Article
- Dosimetric parameters and clinical outcomes of photobiomodulation in diabetic neuropathy: a concise review.Lasers in medical science · 2025Review
- Gastric filling ultrasound in assessing gastrointestinal motility in type 2 diabetic patients with neuropathy: A clinical study.Journal of diabetes investigation · 2025Article
- Diagnostic advancements in early detection of diabetic neuropathy: comparative analysis of medial and lateral plantar nerve degeneration.Annals of medicine and surgery (2012) · 2025Review
- Alpha-Lipoic Acid in Diabetic Peripheral Neuropathy: Addressing the Challenges and Complexities Surrounding a 70-Year-Old Compound.Current issues in molecular biology · 2025Review
- Fruit-Based Diet and Gut Health: A Review.Food science & nutrition · 2025Review
- Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes.World journal of diabetes · 2025Article
- Machine learning-based prediction of diabetic peripheral neuropathy: model development and clinical validation.Frontiers in endocrinology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic sensorimotor polyneuropathy (DSPN) is encountered in approximately one-third of people with diabetes. This, in turn, might markedly impoverish their quality of life, mainly owing to neuropathic pain and foot ulcerations. Painful DSPN might be as frequent as 25% in diabetes patients. Symptoms as a result of DSPN typically comprise pain, paresthesia and numbness in the distal lower limbs. Asymptomatic DSPN might reach 50% among patients with this condition. Unfortunately, DSPN is still not adequately diagnosed and treated. Its management has three priorities: (i) lifestyle improvement, near-normoglycemia and multifactorial cardiovascular risk intervention; (ii) pathogenesis-oriented pharmacotherapy; and (iii) symptomatic alleviation of pain. Intensive diabetes therapy showed evidence for favorable effects on the incidence and deterioration of DSPN in type 1 diabetes, but not type 2 diabetes. Among pathogenesis-oriented treatments, α-lipoic acid, actovegin, benfotiamine and epalrestat are currently authorized to treat DSPN in several countries. Symptomatic therapy uses analgesics, notably antidepressants, opioids and anticonvulsants, reducing pain by ≥50% in approximately 50% of individuals, but might be limited, particularly by central nervous system-related adverse events. Local treatment with the capsaicin 8% patch might offer an alternative. In addition to pain relief, therapy should improve sleep, mobility and quality of life. In conclusion, multimodal treatment of DSPN should consider the individual risk profile, pathogenetic treatment and pain management using pharmacotherapy (combinations, if required), as well as non-pharmacological options.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.