ArticleHippocampus2021
Age-related alterations in functional connectivity along the longitudinal axis of the hippocampus and its subfields.
Article in Hippocampus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain connectivity changes associated with episodic recollection decline in aging: A review of fMRI studies.Frontiers in aging neuroscience · 2022Pooled it
- Age Differences in Hippocampal Neural Timescales During Movie-Viewing.bioRxiv : the preprint server for biology · 2026Article
- Gut-brain health effects of PREbiotics in older adults with suspected COgnitive DEcline: design of the PRECODE randomised placebo-controlled trial.Frontiers in nutrition · 2026Article
- Plasma p-tau217 and p-tau217/AβScientific reports · 2025Article
- Reorganisation of Cortico-Hippocampal White Matter Pathways in Healthy Ageing: Evidence for Paradoxical Shifts in Structural Connectivity.bioRxiv : the preprint server for biology · 2025Article
- Stimulatory Effects of (+)-Epicatechin on Short- and Long-Term Memory in Aged Rats: Underlying Mechanisms.Nutrients · 2025Article
- Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia.Brain : a journal of neurology · 2025Article
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
- Article
- Canonical cortico-hippocampal dynamics underlie memory of navigational episodes and its early decline in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- Acute cycling exercise and hippocampal subfield function and microstructure in healthy older adults.Hippocampus · 2023Article
- Effects of prior knowledge on brain activation and functional connectivity during memory retrieval.Scientific reports · 2023Article
- The Effects of Transcutaneous Vagus Nerve Stimulation on Functional Connectivity Within Semantic and Hippocampal Networks in Mild Cognitive Impairment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Aging and Alzheimer's disease have dissociable effects on local and regional medial temporal lobe connectivity.Brain communications · 2023Article
- Disturbed hippocampal intra-network in first-episode of drug-naïve major depressive disorder.Brain communications · 2023Article
- Alterations in Human Hippocampus Subregions across the Lifespan: Reflections on White Matter Structure and Functional Connectivity.Neural plasticity · 2023Article
- Hippocampus and temporal pole functional connectivity is associated with age and individual differences in autobiographical memory.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Data-Driven Clustering of Functional Signals Reveals Gradients in Processing Both within the Anterior Hippocampus and across Its Long Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Temporal pole volume is associated with episodic autobiographical memory in healthy older adults.Hippocampus · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Hippocampal circuit alterations that differentially affect hippocampal subfields are associated with age-related memory decline. Additionally, functional organization along the longitudinal axis of the hippocampus has revealed distinctions between anterior and posterior (A-P) connectivity. Here, we examined the functional connectivity (FC) differences between young and older adults at high-resolution within the medial temporal lobe network (entorhinal, perirhinal, and parahippocampal cortices), allowing us to explore how hippocampal subfield connectivity across the longitudinal axis of the hippocampus changes with age. Overall, we found reliably greater connectivity for younger adults than older adults between the hippocampus and parahippocampal cortex (PHC) and perirhinal cortex (PRC). This drop in functional connectivity was more pronounced in the anterior regions of the hippocampus than the posterior ones, consistent for each of the hippocampal subfields. Further, intra-hippocampal connectivity also reflected an age-related decrease in functional connectivity within the anterior hippocampus in older adults that was offset by an increase in posterior hippocampal functional connectivity. Interestingly, the anterior-posterior dysfunction in older adults between hippocampus and PHC was predictive of lure discrimination performance on the Mnemonic similarity task (MST), suggesting a role in memory performance. While age-related dysfunction within the hippocampal subfields has been well-documented, these results suggest that the age-related dysfunction in hippocampal connectivity across the longitudinal axis may also contribute significantly to memory decline in older adults.
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