Observational studyJournal of thrombosis and thrombolysis2021
Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery.
Observational study in Journal of thrombosis and thrombolysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Efficacy of tranexamic acid in reducing perioperative blood transfusions and thrombosis in liver surgery: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2025Pooled it
- Is "Physiological Lysis" in Viscoelastometry a Plasmin-Mediated Process?Diagnostics (Basel, Switzerland) · 2026Article
- Rethinking thromboprophylaxis duration after total joint arthroplasty: when historical evidence meets modern surgical practice.Journal of thrombosis and thrombolysis · 2026Article
- A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery.Perioperative medicine (London, England) · 2024Review
- Concentration-effect relationship for tranexamic acid inhibition of tissue plasminogen activator-induced fibrinolysis in vitro using the viscoelastic ClotPro® TPA-test.British journal of anaesthesia · 2024Article
- Comparison of two viscoelastic testing devices in a porcine model of surgery, hemorrhage and resuscitation.Frontiers in bioengineering and biotechnology · 2024Article
- Viscoelastic coagulation testing in Neonatal Intensive Care Units: advantages and pitfalls in clinical practice.Blood transfusion = Trasfusione del sangue · 2023Review
- Fibrinolytic potential as a risk factor for postpartum hemorrhage.Frontiers in medicine · 2023Article
- A comparison of the ClotPro system with rotational thromboelastometry in cardiac surgery: a prospective observational study.Scientific reports · 2022Observational
- [Standard administration of tranexamic acid for prophylaxis in endoprosthetics: a good idea?]Der Orthopade · 2022Article
- Impaired fibrinolysis in critically ill COVID-19 patients.British journal of anaesthesia · 2021Article
- Comparison of the New Viscoelastic Coagulation Analyzer ClotPro® With ROTEM® Delta and Conventional Coagulation Tests in Critically Ill Patients With COVID-19.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and oral administration in patients undergoing elective orthopaedic surgery with lysis variables of TPA-test. Blood samples of 42 patients were evaluated before TXA application and 2, 6, 12, 24 and 48 h afterwards. TPA-test was used to determine lysis time (LT) as well as maximum lysis (ML) and cTXA was measured using Ultra-High-Performance-Liquid-Chromatography/Mass-Spectrometry. Data are presented as median (min-max). LT
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.