ReviewCurrent psychiatry reports2020
Early Life Stress and the Development of the Infant Gut Microbiota: Implications for Mental Health and Neurocognitive Development.
Review in Current psychiatry reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The Gut Microbiome in Early Life Stress: A Systematic Review.Nutrients · 2023Pooled it
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- Sensory Over-Responsivity in Autism: A Bidirectional Brain-Gut-Microbiome Model.Journal of autism and developmental disorders · 2026Article
- Beyond the 'second brain': the gut microbiota as a constitutive co-constructor of embodied cognitive network.Frontiers in neuroscience · 2026Review
- Social Determinants of Health and Early Brain Development.Pediatric clinics of North America · 2025Review
- Longitudinal associations between the infant gut microbiome and negative affect in toddlerhood.Development and psychopathology · 2025Article
- Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile acid pathway.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Associations between relative abundances ofFrontiers in microbiology · 2025Article
- Characteristics of the oral microbiome in youth exposed to caregiving adversity.Brain, behavior, & immunity - health · 2024Article
- Altered Gut Microbiota Patterns in Young Children with Recent Maltreatment Exposure.Biomolecules · 2024Article
- Neurodevelopmental Disorders Associated with Gut Microbiome Dysbiosis in Children.Children (Basel, Switzerland) · 2024Review
- Modulation of gut microbiota composition due to early weaning stress induces depressive behavior during the juvenile period in mice.Animal microbiome · 2024Article
- Role of the GLP2-Wnt1 axis in silicon-rich alkaline mineral water maintaining intestinal epithelium regeneration in piglets under early-life stress.Cellular and molecular life sciences : CMLS · 2024Article
- Implications of Inflammatory Processes on a Developing Central Nervous System in Childhood-Onset Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2024Review
- The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients.Journal of clinical medicine · 2024Review
- Efficacy and safety ofBrain, behavior, & immunity - health · 2023Article
- The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study.Microorganisms · 2023Article
- The impact of early life experiences and gut microbiota on neurobehavioral development among preterm infants: A longitudinal cohort study.medRxiv : the preprint server for health sciences · 2023Article
- Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization.Interdisciplinary nursing research · 2022Article
- Intestinal Microbiota in Children with Anemia in Southern Peru through Next-Generation Sequencing Technology.Children (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewWe review the state of the literature examining associations between early life stress (ELS), gut microbiota, and neurocognitive development and mental health in animals and humans. We identify gaps in current models and areas for future research. RECENT
findingsELS is associated with changes in gut microbiota, which correspond to changes in affective and cognitive functioning in both animals and humans. Some of these ELS-induced psychological changes can be remedied by supplementation with probiotics in early life, suggesting a potential area for intervention for ELS-exposed children. Prenatal stress exposure is rarely studied in humans in relation to gut microbiota, but animal work has suggested important associations between prenatal stress and fetal programming that should be tested in humans. The gut microbiota plays an important role in the association between ELS, neurocognitive development, and mental health. More work is needed to fully understand these associations in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.