ArticleAnnals of hematology2021
Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection.
Article in Annals of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Autoimmune and Rheumatic Manifestations Associated With COVID-19 in Adults: An Updated Systematic Review.Frontiers in immunologyPooled it
- Case Report: COVID-19-associated gangrene of fingers in a patient with autoimmune haemolytic anaemia.Frontiers in medicine · 2026Article
- Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Impact of Hemoglobin Levels on Composite Cardiac Arrest or Stroke Outcome in Patients With Respiratory Failure Due to COVID-19.Critical care explorations · 2024Article
- Simultaneous occurrence of autoimmune hepatitis and autoimmune hemolytic anemia after COVID-19 infection: case report and literature review.Clinical journal of gastroenterology · 2024Review
- Hematological parameters to predict post-COVID-19 immune response among vaccinated and nonvaccinated individuals: a retrospective cross-sectional study.Annals of medicine and surgery (2012) · 2024Article
- Warm autoimmune hemolytic anemia associated with SARS-CoV-2 infection responsive to eculizumab.Annals of hematology · 2024Article
- COVID-19 in patients with anemia and haematological malignancies: risk factors, clinical guidelines, and emerging therapeutic approaches.Cell communication and signaling : CCS · 2024Review
- Integration of individualized and population-level molecular epidemiology data to model COVID-19 outcomes.Cell reports. Medicine · 2024Article
- Could Anemia Impact the Severity of Infections? COVID-19 as an Example.F1000Research · 2024Article
- Clinical efficacy of Fufang Yinhua Jiedu (FFYH) granules in mild COVID-19 and its anti-SARS-CoV-2 mechanism by blocking autophagy through inhibiting the AKT/mTOR signaling pathway.Frontiers in pharmacology · 2024Article
- Impact of hyperchloremia on inflammatory markers, serum creatinine, hemoglobin, and outcome in critically ill patients with COVID-19 infection.Journal of medicine and life · 2023Article
- Alterations of erythropoiesis in Covid-19 patients: prevalence of positive Coombs tests and iron metabolism.Therapeutic advances in hematology · 2023Article
- Case mistaken for leukemia after mRNA COVID-19 vaccine administration: A case report.World journal of clinical cases · 2022Article
- Hemolytic anemia in COVID-19.Annals of hematology · 2022Review
- Positive direct antiglobulin tests in cancer patients hospitalized with COVID-19: A brief report from India.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2022Article
- The significance of antiglobulin (Coombs) test reactivity in patients with COVID-19.Immunobiology · 2022Article
- The Dysregulation of the Renin-Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity.Molecules (Basel, Switzerland) · 2022Article
- Pulmonary fibrosis in patients with COVID-19: A retrospective study.Frontiers in cellular and infection microbiology · 2022Article
- Is hemolysis a novel therapeutic target in COVID-19?Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher levels of D-dimer, LDH, and ferritin, all have been associated with the poor prognosis of COVID-19. In a disease where there are acute inflammation and compromised oxygenation, we investigated the impact of initial hemoglobin (Hgb) levels at Emergency Department (ED) triage on the severity and the clinical course of COVID-19. We conducted a cross-sectional study on 601 COVID-19 patients in a COVID-19 national referral center between 13 and 27 June 2020. All adult patients presented at our hospital that required admission or hotel isolation were included in this study. Patients admitted to the intensive care unit (ICU) had a lower initial Hgb than those admitted outside the ICU (12.84 g/dL vs. 13.31 g/dL, p = 0.026) and over the course of admission; the prevalence of anemia (Hgb < 12.5 g/dL) was 65% in patients admitted to ICU, whereas it was only 43% in non-ICU patients (odds ratio of 2.464, 95% CI 1.71-3.52). Anemic ICU patients had a higher mortality compared with non-anemic ICU patients (hazard ratio = 1.88, log-rank p = 0.0104). A direct agglutination test (DAT) for all anemic patients showed that 14.7% of ICU patients and 9% of non-ICU patients had autoimmune hemolytic anemia (AIHA). AIHA patients had significantly longer length of hospital stay compared with anemic patients without AIHA (17.1 days vs. 14.08 days, p = 0.034). Lower Hgb level at hospital presentation could be a potential surrogate for COVID-19 severity.
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