Evidence map›Paper›PMID 32918333›Full record

ArticleJournal of cellular biochemistry2021

PARK7 enhances antioxidative-stress processes of BMSCs via the ERK1/2 pathway.

Fei Zhang, Wuxun Peng, Jian Zhang, Lei Wang, Wentao Dong, Yinggang Zheng, Zhenwen Wang, Zhihong Xie, Tao Wang, Chuan Wang and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  14. PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases.International journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fei ZhangDepartment of Traumatologic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Wuxun PengDepartment of Traumatologic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.ORCID 0000-0001-9468-2580
Jian ZhangDepartment of Traumatologic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Lei WangDepartment of Statistics, Guizhou Maternal and Child Health Hospital, Guiyang, Guizhou, China.
Wentao DongDepartment of Traumatologic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Yinggang ZhengDepartment of Orthopedics, The Affiliated Wudang Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Zhenwen WangDepartment of Orthopedics, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Zhihong XieSchool of clinical medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Tao WangSchool of clinical medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Chuan WangSchool of clinical medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Yanglin YanSchool of clinical medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Guiyang Medical University · CNGuizhou Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stresss in the microenvironment surrounding lesions induces apoptosis of transplanted bone-marrow-derived mesenchymal stem cells (BMSCs). Hence, there is an urgent need for improving antioxidative-stress processes of transplanted BMSCs to further promote their survival. The present study reports the role and mechanism of Parkinson's disease protein 7 (PARK7) in enhancing antioxidative activity in BMSCs. We used a PARK7 lentivirus to transfect BMSCs to up- or downregulate PARK7, and then used H

Indexed as

AnimalsApoptosisButadienesHumansMalondialdehydeMAP Kinase Signaling SystemMembrane Potential, MitochondrialMesenchymal Stem CellsNitrilesOxidative StressParkinson DiseaseProtein Deglycase DJ-1Reactive Oxygen SpeciesSuperoxide DismutaseButadienesMalondialdehydeNitrilesProtein Deglycase DJ-1Reactive Oxygen SpeciesSuperoxide DismutaseU 0126bone-marrow-derived mesenchymal stem cellsextracellular-regulated protein kinase 1/2oxidative stressParkinson's disease protein 7

Identifiers

PMID32918333
PMCPMC7820948
OpenAlexW3195904209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.