Evidence map›Paper›PMID 32918195›Full record

ReviewCurrent HIV/AIDS reports2020

Are We There Yet? Short-Course Regimens in TB and HIV: From Prevention to Treatment of Latent to XDR TB.

Elisa H Ignatius, Susan Swindells

Open access · greenAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Evaluation of theFrontiers in cellular and infection microbiology · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Elisa H IgnatiusJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Susan SwindellsUniversity of Nebraska Medical Center, Omaha, NE, 68198-8106, USA. sswindells@unmc.edu.ORCID 0000-0001-5826-6037
Johns Hopkins University · USNebraska Medical Center · US

Funding

Clinical Pharmacology Training ProgramT32GM066691 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Matthew Michael Ippolito · 2003 to 2026
$6.4M
Optimizing Anti-mycobacterial Therapy Using A Pharmacology-based ApproachK23AI159145 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Elisa Helen Ignatius · 2022 to 2026
$994k
NIAID NIH HHS K23 AI159145NIGMS NIH HHS T32 GM066691
6 · The paper itself

Abstract

purpose of reviewDespite broad uptake of antiretroviral therapy (ART), tuberculosis (TB) incidence and mortality among people with HIV remain unacceptably high. Short-course regimens for TB, incorporating both novel and established drugs, offer the potential to enhance adherence and completion rates, thereby reducing the global TB burden. This review will outline short-course regimens for TB among patients with HIV. RECENT

findingsAfter many years without new agents, there is now active testing of many novel drugs to treat TB, both for latent infection and active disease. Though not all studies have included patients with HIV, many have, and there are ongoing trials to address key implementation challenges such as potent drug-drug interactions with ART. The goal of short-course regimens for TB is to enhance treatment completion without compromising efficacy. Particularly among patients with HIV, studying these shortened regimens and integrating them into clinical care are of urgent importance. There are now multiple short-course regimens for latent infection and active disease that are safe and effective among patients with HIV.

Indexed as

Anti-HIV AgentsAntitubercular AgentsDrug InteractionsExtensively Drug-Resistant TuberculosisHIV InfectionsHumansIsoniazidPyrazinamideRifampinTuberculosis, PulmonaryAnti-HIV AgentsAntitubercular AgentsIsoniazidPyrazinamideRifampinrifapentineDrug-drug interactionsDrug-resistant tuberculosisDrug-susceptible tuberculosisHIV infectionTuberculosisTuberculosis preventive therapy

Identifiers

PMID32918195
PMCPMC9178518
OpenAlexW3086131504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.