Evidence map›Paper›PMID 32918118›Full record

ArticleActa neuropathologica2020

Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt-Jakob disease.

Luke C Dabin, Fernando Guntoro, Tracy Campbell, Tony Bélicard, Adam R Smith, Rebecca G Smith, Rachel Raybould, Jonathan M Schott, Katie Lunnon, Peter Sarkies and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. DNA methylation as a contributor to dysregulation ofbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Epigenetics in Alzheimer's Disease.Frontiers in aging neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Luke C DabinMRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.ORCID 0000-0001-6365-291X
Fernando GuntoroMRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Tracy CampbellMRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Tony BélicardMRC London Institute of Medical Sciences Du Cane Road London W12 0NN and Institute of Clinical Sciences, Imperial College London Du Cane Road London W12 0NN, Imperial College London, London, W12 0NN, UK.
Adam R SmithCollege of Medicine and Health, University of Exeter Medical School, Exeter University, RILD Building Level 4, Royal Devon and Exeter Hospital, Barrack Rd, Exeter, EX2 5DW, UK.
Rebecca G SmithCollege of Medicine and Health, University of Exeter Medical School, Exeter University, RILD Building Level 4, Royal Devon and Exeter Hospital, Barrack Rd, Exeter, EX2 5DW, UK.
Rachel RaybouldInstitute of Psychological Medicine and Clinical Neurosciences, Cardiff University, UHW Main Building, Heath Park, Cardiff, CF14 4XN, UK.
Jonathan M SchottDementia Research Centre, UCL Institute of Neurology, 8-11 Queen Square, London, WC1N 3AR, UK.
Katie LunnonCollege of Medicine and Health, University of Exeter Medical School, Exeter University, RILD Building Level 4, Royal Devon and Exeter Hospital, Barrack Rd, Exeter, EX2 5DW, UK.ORCID 0000-0001-7570-6065
Peter SarkiesMRC London Institute of Medical Sciences Du Cane Road London W12 0NN and Institute of Clinical Sciences, Imperial College London Du Cane Road London W12 0NN, Imperial College London, London, W12 0NN, UK.
John CollingeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Simon MeadMRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK. s.mead@prion.ucl.ac.uk.
Emmanuelle ViréMRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.ORCID 0000-0002-7868-9923
MRC Prion Unit · GBUniversity of Exeter · GBMRC London Institute of Medical Sciences · GBCardiff University · GBUK Dementia Research Institute · GB

Funding

Medical Research Council G0400713Medical Research Council MC_U123160651Medical Research Council MC_U123160657Medical Research Council MC_UU_00024/1Medical Research Council MC_UU_00024/9
6 · The paper itself

Abstract

Prion diseases are fatal and transmissible neurodegenerative disorders caused by the misfolding and aggregation of prion protein. Although recent studies have implicated epigenetic variation in common neurodegenerative disorders, no study has yet explored their role in human prion diseases. Here we profiled genome-wide blood DNA methylation in the most common human prion disease, sporadic Creutzfeldt-Jakob disease (sCJD). Our case-control study (n = 219), when accounting for differences in cell type composition between individuals, identified 38 probes at genome-wide significance (p < 1.24 × 10

Indexed as

AdultAgedAged, 80 and overAlzheimer DiseaseBrainCase-Control StudiesCreutzfeldt-Jakob SyndromeDNA MethylationFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPrion DiseasesShaker Superfamily of Potassium ChannelsShaker Superfamily of Potassium ChannelsBloodDisease durationDNA methylationNeurodegenerationPrion diseasesCJD

Identifiers

PMID32918118
PMCPMC7666287
OpenAlexW3085505087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.