ArticleArchives of microbiology2021
Gene expressing analysis indicates the role of Pyrogallol as a novel antibiofilm and antivirulence agent against Acinetobacter baumannii.
Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Structure-based virulence factor classification using a dual-driven graph transformer with a pretrained language model.Briefings in bioinformatics · 2026Article
- Antibiofilm and antivirulence effects of cinnamaldehyde on Acinetobacter baumannii.Molecular biology reports · 2026Article
- Therapeutic significance of surface-exposed virulence factors in Acinetobacter baumannii pathogenicity.Molecular biology reports · 2026Review
- Antivirulence drugs against Acinetobacter baumannii: where do they stand?World journal of microbiology & biotechnology · 2025Review
- Subinhibitory Concentrations of Oxacillin Alter Motility, Biofilm Production, and Transformation Capability of the Oxacillinase-Producing Acinetobacter baumannii.Current microbiology · 2025Article
- Evaluation of Bcr/cflA Targeted Efflux Inhibitory Potential of 2-Hydroxy-4-Methoxybenzaldehyde AgainstIndian journal of microbiology · 2025Article
- Motility of Acinetobacter baumannii: regulatory systems and controlling strategies.Applied microbiology and biotechnology · 2024Review
- High-throughput combination assay for studying biofilm formation of uropathogenic Escherichia coli.Archives of microbiology · 2024Article
- Selection and validation of reference genes suitable for gene expression analysis by Reverse Transcription Quantitative real-time PCR in Acinetobacter baumannii.Scientific reports · 2024Article
- Zingerone inhibits biofilm formation and enhances antibiotic efficacy against Salmonella biofilm.World journal of microbiology & biotechnology · 2023Article
- The Mechanism of Tigecycline Resistance inInternational journal of molecular sciences · 2023Article
- Attenuation of quorum sensing system and virulence inFrontiers in microbiology · 2023Article
- Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.Microorganisms · 2022Review
- Gram-Negative Bacteria Holding Together in a Biofilm: TheMicroorganisms · 2021Review
- Pyrogallol and Fluconazole Interact SynergisticallyAntimicrobial agents and chemotherapy · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acinetobacter baumannii has emerged worldwide as a leading cause of hospital-acquired infections. Although A. baumannii was initially regarded to as a low-grade pathogen, evidence has been accumulated suggesting that A. baumannii infections are associated with increased mortality in critically ill patients. Here, we describe the efficacy of pyrogallol, a polyphenolic organic compound found in the galls and barks of various trees, which shows anti-biofilm and anti-virulence potential against A. baumannii. Pyrogallol shows concentration-based biofilm inhibition, as evidenced through light and confocal laser scanning microscopic analysis. The other virulence factors are protease, swarming motility, and extracellular polymeric substances that are also inhibited by pyrogallol. Through real-time PCR, it was found that pyrogallol downregulates expression of the biofilm and virulence-related ompA, bap, csuA/B, katE, pgaA, and pgaC genes. Furthermore, pyrogallol moderately inhibited the mature biofilms of A. baumannii in a concentration-dependent manner (5, 10, and 20 µg/ml). The present study reports that the anti-biofilm and anti-virulence potential of pyrogallol disrupts the biofilm formation, adherence of cells, and cell-to-cell signaling mechanism of A. baumannii. Thus, pyrogallol is a promising therapeutic agent for A. baumannii-related infections.
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