ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021
Antibiotic Overuse After Hospital Discharge: A Multi-hospital Cohort Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06106204 (A Parallel Cluster Randomized Trial of a Participatory Approach to Reduce Overuse of Antibiotics at Hospital Discharge), which is not on this map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Parallel Cluster Randomized Trial of a Participatory Approach to Reduce Overuse of Antibiotics at Hospital Discharge: The ROAD Home Trial
Who cites it
43 citing papers in PubMed, 66 citations in OpenAlex.
- Prospective Audit and Feedback by Antibiotic Stewardship Teams to Reduce Antibiotic Overuse at Hospital Discharge: A Stepped-Wedge Cluster-Randomized Clinical Trial.JAMA network open · 2026Trial
- Effect of host-protein test (TRAIL/IP-10/CRP) on antibiotic prescription and emergency department or urgent care center return visits: The JUNO pilot randomized controlled trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025Trial
- Reducing overuse of antibiotics at discharge home: A single-center mixed methods pilot study.American journal of infection control · 2022Trial
- Electronic Clinical Quality Measures of Antibiotic Use in Hospitalized Adults With Uncomplicated Community-Acquired Pneumonia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Prolonged antibiotic treatment durations for community-onset infections in Dutch hospitals.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Impact of a structured urine culture request form on antimicrobial stewardship in urinary tract infections at a tertiary care hospital in India.Frontiers in antibiotics · 2026Article
- Antibiotic Stewardship at transitions of care: identifying opportunities for antibiotic optimization.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Qualitative assessment of antibiotic stewardship teams' efforts to perform prospective audit-and-feedback at hospital discharge.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Review
- National Survey of Factors Associated with Physician Antibiotic Prescribing Preferences.Journal of general internal medicine · 2025Article
- Unraveling indications for discharge antibiotics: the Devil's in the details.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Antimicrobial stewardship initiative on prescribing at discharge from a community medical center.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Tailor swiftly: lessons learned from a nationwide implementation of an antimicrobial stewardship program for asymptomatic bacteriuria.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Effects of antibiotics ceftriaxone and levofloxacin on the growth of Protophormia terraenovae (Diptera: Calliphoridae).Forensic science, medicine, and pathology · 2024Article
- Influence of Drugs and Toxins on Decomposition Dynamics: Forensic Implications.Molecules (Basel, Switzerland) · 2024Review
- A Novel Risk-Adjusted Metric to Compare Hospitals on Their Antibiotic Prescribing at Hospital Discharge.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Follow-up of patients with urinary tract infections discharged from the emergency department: a mixed methods study.The Journal of antimicrobial chemotherapy · 2024Observational
- Excellence in Antibiotic Stewardship: A Mixed-Methods Study Comparing High-, Medium-, and Low-Performing Hospitals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Proposing the "Continuum of UTI" for a Nuanced Approach to Diagnosis and Management of Urinary Tract Infections.The Journal of urology · 2024Article
- Protocol for a parallel cluster randomized trial of a participatory tailored approach to reduce overuse of antibiotics at hospital discharge: the ROAD home trial.Implementation science : IS · 2024Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAntibiotics are commonly prescribed to patients as they leave the hospital. We aimed to create a comprehensive metric to characterize antibiotic overuse after discharge among hospitalized patients treated for pneumonia or urinary tract infection (UTI), and to determine whether overuse varied across hospitals and conditions.
methodsIn a retrospective cohort study of hospitalized patients treated for pneumonia or UTI in 46 hospitals between 1 July 2017-30 July 2019, we quantified the proportion of patients discharged with antibiotic overuse, defined as unnecessary antibiotic use, excess antibiotic duration, or suboptimal fluoroquinolone use. Using linear regression, we assessed hospital-level associations between antibiotic overuse after discharge in patients treated for pneumonia versus a UTI.
resultsOf 21 825 patients treated for infection (12 445 with pneumonia; 9380 with a UTI), nearly half (49.1%) had antibiotic overuse after discharge (56.9% with pneumonia; 38.7% with a UTI). For pneumonia, 63.1% of overuse days after discharge were due to excess duration; for UTIs, 43.9% were due to treatment of asymptomatic bacteriuria. The percentage of patients discharged with antibiotic overuse varied 5-fold among hospitals (from 15.9% [95% confidence interval, 8.7%-24.6%] to 80.6% [95% confidence interval, 69.4%-88.1%]) and was strongly correlated between conditions (regression coefficient = 0.85; P < .001).
conclusionsAntibiotic overuse after discharge was common and varied widely between hospitals. Antibiotic overuse after discharge was associated between conditions, suggesting that the prescribing culture, physician behavior, or organizational processes contribute to overprescribing at discharge. Multifaceted efforts focusing on all 3 types of overuse and multiple conditions should be considered to improve antibiotic prescribing at discharge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.