Evidence map›Paper›PMID 32917946›Full record

SynthesisScientific reports2020

Diagnostic value of four neuroendocrine markers in small cell neuroendocrine carcinomas of the cervix: a meta-analysis.

Rui Huang, Li Yu, Chunying Zheng, Qingchun Liang, Suye Suye, Xue Yang, Huan Yin, Zhen Ren, Liye Shi, Zhibang Zhang and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rui HuangDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li YuDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chunying ZhengDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qingchun LiangDepartment of Pathology, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Suye SuyeDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xue YangDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huan YinDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhen RenDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liye ShiDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhibang ZhangDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hongliang ChenDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chun FuDepartment of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. fuchun0814@csu.edu.cn.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small cell neuroendocrine carcinoma of the cervix (SCNECC) is a highly invasive cervical cancer. The immunohistochemical criteria is an important aspect for assistant diagnosis of SCNECC. However, which markers can be appropriate selection for diagnosing SCNECC were not determined. The aim was to systematically evaluate expression levels of four neuroendocrine markers (containing synaptophysin (Syn), neural cell adhesion molecules (CD56), neuron-specific enolase (NSE) and chromograninA (CgA)) and to find out the appropriate selection for diagnosing SCNECC. Four English and three Chinese libraries were retrieved between 1984 and 2020. 23 studies about NSE, 36 studies about Syn, 23 studies about CD56 and 36 studies about CgA (all studies containing 581 patients) were eligible for meta-analyses. The pooled positive expression percentages (95% CI; I

Indexed as

Carcinoma, NeuroendocrineCarcinoma, Small CellUterine Cervical NeoplasmsBiomarkers, TumorFemaleHumansNeoplasm ProteinsBiomarkers, TumorNeoplasm Proteins

Identifiers

PMID32917946
PMCPMC7486403
OpenAlexW3084988572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.