ArticleCommunications biology2020
A flavin-dependent monooxygenase catalyzes the initial step in cyanogenic glycoside synthesis in ferns.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Biosynthesis of pathogen-induced hydroxylated tryptamine derivatives in barley.Plant physiology · 2026Article
- Plasticity-first evolution via CYP405 loss shaped chemical defenses in butterflies.Molecular biology and evolution · 2026Article
- β-cell FMO3-produced TMAO prevents NF-κB-mediated senescence and inflammation in ageing and diabetic conditions.Nature communications · 2026Article
- Aldoximes serve as auxin precursors and repress phenylpropanoid metabolism in tomato.bioRxiv : the preprint server for biology · 2026Article
- Flavin-dependent monooxygenases as versatile biocatalysts in biomanufacturing: mechanisms, engineering, and applications.Biotechnology for biofuels and bioproducts · 2026Review
- Cross-kingdom RNA interference promotes arbuscular mycorrhiza development.Nature plants · 2026Article
- Cyanogenic millipede genome illuminates convergent evolution of cyanogenesis-related enzymes.PLoS genetics · 2025Article
- Engineering auxin degradation into root-associated bacteria promotes plant growth.bioRxiv : the preprint server for biology · 2025Article
- Plant cyanogenic glycosides: from structure to properties and potential applications.Frontiers in plant science · 2025Review
- A Convenient Route to Large-Scale Chemical Synthesis ofACS omega · 2024Article
- A bird's-eye view: exploration of the flavin-containing monooxygenase superfamily in common wheat.Frontiers in plant science · 2024Article
- Reinventing metabolic pathways: Independent evolution of benzoxazinoids in flowering plants.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2023Article
- Occurrence, Function, and Biosynthesis of the Natural Auxin Phenylacetic Acid (PAA) in Plants.Plants (Basel, Switzerland) · 2023Review
- Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny.BBA advances · 2023Article
- Metabolic link between auxin production and specialized metabolites in Sorghum bicolor.Journal of experimental botany · 2023Article
- Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals.Molecular biology and evolution · 2022Article
- A flavin-dependent monooxygenase produces nitrogenous tomato aroma volatiles using cysteine as a nitrogen source.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cyanogenesis in theGenes · 2022Article
- Aldoximes are precursors of auxins in Arabidopsis and maize.The New phytologist · 2021Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Cyanogenic glycosides form part of a binary plant defense system that, upon catabolism, detonates a toxic hydrogen cyanide bomb. In seed plants, the initial step of cyanogenic glycoside biosynthesis-the conversion of an amino acid to the corresponding aldoxime-is catalyzed by a cytochrome P450 from the CYP79 family. An evolutionary conundrum arises, as no CYP79s have been identified in ferns, despite cyanogenic glycoside occurrence in several fern species. Here, we report that a flavin-dependent monooxygenase (fern oxime synthase; FOS1), catalyzes the first step of cyanogenic glycoside biosynthesis in two fern species (Phlebodium aureum and Pteridium aquilinum), demonstrating convergent evolution of biosynthesis across the plant kingdom. The FOS1 sequence from the two species is near identical (98%), despite diversifying 140 MYA. Recombinant FOS1 was isolated as a catalytic active dimer, and in planta, catalyzes formation of an N-hydroxylated primary amino acid; a class of metabolite not previously observed in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.